Results 81 to 90 of about 2,070,422 (305)

Development and evaluation of an inhalation chamber for in vivo tests

Anais da Academia Brasileira de Ciências, 2017
The bioavailability, toxicity, and therapeutic efficacy of a drug is directly related to its administration route. The pulmonary route can be accessed by inhalation after fumigation, vaporization or nebulization.
EDUARDO R. DA SILVA, HUMBERTO R. BIZZO, PATRÍCIA D. FERNANDES, VALDIR F. DA VEIGA JUNIOR, SUZANA G. LEITÃO, DANILO R. DE OLIVEIRA   +5 more
doaj   +1 more source

Soft Robotic Excretory Care Simulator for Nursing Education: Functional and Perceptual Biomimetics Approach

Advanced Robotics Research, EarlyView.
A soft robotic simulator is developed to replicate the digital removal of feces (DRF), a sensitive yet essential nursing procedure. Integrating soft actuators, sensors, and a realistic rectal model, the simulator balances functional fidelity with perceptual realism. Engineering evaluations and nurse feedback confirm its potential to enhance training in
Shoko Miyagawa, Sota Suzuki, Shizuka Watanabe, Zebing Mao, Young Ah Seong, Toshinori Fujie, Tatsuhiro Horii, Kenjiro Tadakuma, Koichi Suzumori, Hiroyuki Nabae, Shingo Maeda   +10 more
wiley   +1 more source

PREVALÊNCIA E PREDITORES DO USO INCORRETO DOS DISPOSITIVOS INALATÓRIOS EM PACIENTES PORTADORES DE DOENÇA PULMONAR OBSTRUTIVA CRÔNICA

Revista Educação em Saúde, 2015
Objective: To determine the prevalence and predictors of incorrect use of inhalers in ambulatory patients with chronic obstructive pulmonary disease (COPD).
Giovanna Agda Moraes Mesquita, Jéssica Souza Ferro, Roberta Martins Carlos Alves, José Laerte Rodrigues da Silva Júnior, Carolina Gomes Machado   +4 more
doaj  

Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake

Toxics
Mechanically fibrillated cellulose nanofibers, known as fib-CNF (fiber length: 500 nm; diameter: 45 nm), are used in composites and as a natural thickener in foods. To evaluate their safety, we conducted a 28-day study in mice with inhalation exposure at
Yoshihiro Yamashita, Akinori Tokunaga, Koji Aoki, Tamotsu Ishizuka, Hideyuki Uematsu, Hiroaki Sakamoto, Satoshi Fujita, Shuichi Tanoue   +7 more
doaj   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Pharmaceutical Benefits of Fluticasone Propionate Association to Delivery Systems: In Vitro and In Vivo Evaluation

Pharmaceutics, 2019
The objective of the present work was to characterize the ability of liposomes and cyclodextrin (CyD) complexes to modulate the in vivo profile of fluticasone (FTZ). In vitro cell compatibility tests were performed, exposing A549 cells to FTZ in the free
Marina G. Dogbe, Ambinintsoa Yattussia Mafilaza, Carla Vânia Eleutério, Helena Cabral-Marques, Sandra Simões, Maria Manuela Gaspar   +5 more
doaj   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

In vitro atomization analysis and evaluation of inhalable sodium sivelestat formulations.

PLoS ONE
The purpose of this paper was to study in vitro atomization properties of the self-developed sodium sivelestat for inhalation, evaluate the feasibility of this preparation as an aerosol inhalation, and provide the guidance for the following animal ...
Rangdong Liu, Aifang He, Yan Xu, Yisheng Zhou, Hui Cao   +4 more
doaj   +1 more source

THE EFFECT OF N-ACETYL CYSTEINE TO SPERM MOTILITY, VIABILITY, AND CONCENTRATION OF SPRAGUE DAWLEY RATS WITH NICOTINE INHALATION EXPOSURE

Jurnal Urologi Indonesia, 2019
Objective: To prove and analyze the difference of sperm motility, viability, and concentration of Sprague Dawley rats which were exposed to nicotine inhalation, with rats treated with N-acetyl cysteine (NAC) orally and exposed to nicotine inhalation ...
Dwi Waskito, Johan Renaldo, Doddy M Soebadi   +2 more
doaj   +1 more source

Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis

Advanced Science, EarlyView.
A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu, Priyanka G. Bhosale, Vishal Kumar, Jeyrroy Gabriel, Shiyue Liu, Ciro Chiappini, Richard J. Cook, Mads S. Bergholt   +7 more
wiley   +1 more source