Results 71 to 80 of about 1,979,787 (310)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Bonneville Power Administration 1998 Annual Report.

, 1998
This is the 1998 annual report to the President by the Administrator and Chief Executive Officer of the Bonneville Power Administration. The topics of the report include financial highlights, letter to the President, review of 1998, financial data ...
United States. Bonneville Power Administration.
core   +1 more source

A new sighting study for the fixed concentration procedure to allow for gender differences [PDF]

, 2011
The fixed concentration procedure (FCP) has been proposed as an alternative to the median lethal concentration (LC50) test (organisation for economic co-operation and development (OECD) test guideline [TG] 403) for the assessment of acute inhalation ...
Creton, Stuart, Indans, Ian, Price, Charlotte L, Edwards, Philippa, Guest, Robert, Griffiths, David, Stallard, Nigel   +6 more
core   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Multiwavelength Implantable Oximeter for Wireless Monitoring of Tissue Oxygenation in the Presence of Blood Volume Changes

Advanced Healthcare Materials, EarlyView.
This study presents an implantable, wireless, battery‐free oximeter that can continuously monitor physiologically consistent regional tissue oxygenation under dynamic changes of blood volume. This is achieved through multiwavelength photoplethysmography and validated both via Monte Carlo simulations and in vivo rat studies. Different stress events were
Anat Usatinsky, Hugo L. Higueros‐Garcia, Sadi Loai, Samantha Unger, Jacob Trueb, Yonatan Usatinsky, Rawad Alkallas‐Valdiviezo, Noor Abu Jarad, Jonathan Wu, Hai‐Ling M. Cheng, John A. Rogers, Abraham Vázquez‐Guardado, Daniel Franklin   +12 more
wiley   +1 more source

Effect of inhaled iloprost on gas exchange in inhalation injury

Burns Open, 2017
Objective: Inhalation injury is an independent risk factor for mortality in burn patients. The purpose of this study was to observe the effect of inhaled iloprost on gas exchange in patients with inhalation injury and acute respiratory failure as ...
Andrea Sikora Newsome, Said Sultan, Brian Murray, Samuel W. Jones, Ashley Pappas, Keith T. Schmidt, Guillaume Filteau, Jeffrey P. Laux, Adam Wolfe, Felicia Williams, Bruce A. Cairns   +10 more
doaj   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Antiviral inhalation medicinal product based on interferon alpha-2b: A study of efficacy, subchronic toxicity, and toxicokinetics in rodents

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Developing high-dose interferon-based medicinal products (MPs) is particularly relevant for effective causal treatment of acute respiratory viral infections, influenza, and COVID-19 coronavirus infection.
N. V. Pankova, I. A. Leneva, I. N. Falynskova, A. V. Ivanina, E. S. Korovkina, O. E. Khuttunen, A. S. Kiryanova, S. V. Sheremetyev, D. V. Lonshakov   +8 more
doaj   +1 more source

Xenon Exerts Neuroprotective Effects on Kainic Acid-Induced Acute Generalized Seizures in Rats via Increased Autophagy

Frontiers in Cellular Neuroscience, 2020
Xenon has been shown to have neuroprotective effects and is clinically used as a favorable safe inhalation anesthetic. We previously confirmed the neuroprotective effects of xenon treatment in epileptic animals.
Wei Zhu, Jianguo Zhu, Shengfa Zhao, Jieqing Li, Dianjun Hou, Yurong Zhang, Hongliu Sun   +6 more
doaj   +1 more source