Results 51 to 60 of about 2,696,581 (351)

Digital technology for monitoring adherence to inhaled therapies in people with cystic fibrosis

, 2023
Background: Improved understanding and treatment of cystic fibrosis (CF) has led to longer life expectancy, which is accompanied by an increasingly complex regimen of treatments.Suboptimal adherence to the treatment plan, in the context of respiratory ...
Smyth, Alan R, Rebecca Calthorpe, Herbert, Sophie, Smith, Sherie, Sherie Smith, Sophie Herbert, Alan R Smyth, Calthorpe, Rebecca   +7 more
core   +1 more source

Modifying and Integrating in vitro and ex vivo Respiratory Models for Inhalation Drug Screening

Frontiers in Bioengineering and Biotechnology, 2020
For the past 50 years, the route of inhalation has been utilized to administer therapies to treat a variety of respiratory and pulmonary diseases. When compared with other drug administration routes, inhalation offers a targeted, non-invasive approach to
Aylin Cidem, P. Bradbury, D. Traini, H. Ong   +3 more
semanticscholar   +1 more source

Evaluation of asthma control, parents’ quality of life and preference between AeroChamber Plus and AeroChamber Plus Flow-Vu spacers in young children with asthma

, 2015
Objective: The AeroChamber Plus (AC) valved holding chamber has been enhanced to include the Flow-Vu (FV) inspiratory flow indicator that provides visual inhalation feedback during use. We have investigated if FV alters asthma control and whether parents
Toor, Sophie, Ammari, Wesam G., Stephenson, John, Chrystyn, Henry, Chetcuti, Philip   +4 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Inhalation of itraconazole mitigates bleomycin-induced lung fibrosis via regulating SPP1 and C3 signaling pathway pivotal in the interaction between phagocytic macrophages and diseased fibroblasts

Journal of Translational Medicine
Background Idiopathic pulmonary fibrosis (IPF) stands as a significant contributor to global mortality rates. Presently, there exists a dearth of effective anti-fibrotic treatments for this condition.
Caizhe Pan, Hao Wei, Bi Chen, Lei Wu, Jiayao Song, Qing Zhang, Xinglong Wu, Guibai Liang, Wenhao Chen, Yingshuo Wang, Yicheng Xie   +10 more
doaj   +1 more source

How Intuitive Is the Administration of Pediatric Emergency Medication Devices for Parents? Objective Observation and Subjective Self-Assessment

Pharmacy
Background: to assess the intuitiveness of parents’ administration of pediatric emergency devices (inhalation, rectal, buccal, nasal, and auto-injector).
Ruth Melinda Müller, Birthe Herziger, Sarah Jeschke, Martina Patrizia Neininger, Thilo Bertsche, Astrid Bertsche   +5 more
doaj   +1 more source

Silicone wristbands integrate dermal and inhalation exposures to semi-volatile organic compounds (SVOCs)

Environment International, 2019
Silicone wristbands are being increasingly used to assess human exposure to semi-volatile organic compounds (SVOCs). However, it is unclear what exposure pathways wristbands integrate.
Shaorui Wang, Kevin A. Romanak, W. Stubbings, V. Arrandale, M. Hendryx, M. Diamond, A. Salamova, M. Venier   +7 more
semanticscholar   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route.

European journal of pharmaceutics and biopharmaceutics
Design of inhalable mRNA therapeutics is promising, because local administration in the respiratory tract is minimally invasive and induces a local response.
Melike Ongun, A. Lokras, S. Baghel, Z. Shi, S. Schmidt, Henrik Franzyk, T. Rades, Federica Sebastiani, Aneesh Thakur, C. Foged   +9 more
semanticscholar   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source