Results 261 to 270 of about 96,185 (308)

Intranasal estradiol administration to oophorectomized women

European Journal of Obstetrics & Gynecology and Reproductive Biology, 1991
An open, dose-finding study into the effects of a new intranasal 17 beta-estradiol formulation using dimethyl-beta-cyclodextrin as a solubilizer was conducted in nine hysterectomized and oophorectomized patients with symptoms of estrogen deficiency. After nasal delivery of 0.34 mg estradiol in three patients, concentration-time curves of estradiol in ...
W A, Hermens, C W, Belder, J M, Merkus, P M, Hooymans, J, Verhoef, F W, Merkus   +5 more
openaire   +2 more sources

Intranasal Administration

Journal of the American College of Toxicology, 1994
The intranasal route has gained increased popularity in the pharmaceutical industry in recent years, particularly because of the number of new peptide therapeutic agents. This has led to a corresponding increase in both interest in and performance of toxicity (or as they are called in the pharmaceutical industry, safety assessment) studies by this ...
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Concentrated Midazolam for Intranasal Administration

Pediatric Emergency Care, 2011
N ...
Calligaris, Lorenzo, Davide, Zanon, Alessandra, Maestro, DE BORTOLI, ROMINA, Chiaretti, Antonio, Barbi, Egidio   +5 more
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Brain distribution of ribavirin after intranasal administration

Antiviral Research, 2011
Ribavirin has proved to be effective in vitro against several RNA viruses responsible for encephalitis in humans and animals. However, the in vivo efficacy towards the cerebral viral load seems to be limited by the blood-brain barrier. Since the nose-to-brain pathway has been indicated for delivering drugs to the brain, we investigated here the ...
Colombo G., LORENZINI, LUCA, ZIRONI, ELISA, GALLIGIONI, VIOLA, Sonvico F., Balducci A.G., PAGLIUCA, GIAMPIERO, GIULIANI, ALESSANDRO, CALZA', LAURA, SCAGLIARINI, ALESSANDRA   +9 more
openaire   +4 more sources

Salivary vasopressin increases following intranasal oxytocin administration

Peptides, 2013
Extant research has documented the effects of intranasal administration of oxytocin (OT), and to a lesser degree Arginine Vasopressin (AVP) - two structurally-related neuropeptides - on brain and behaviour, yet the effects of exogenous manipulation of one on circulating levels of the other remain unknown.
Omri, Weisman, Inna, Schneiderman, Orna, Zagoory-Sharon, Ruth, Feldman   +3 more
openaire   +2 more sources

Pharmacokinetics and Pharmacodynamics of Midazolam After Intranasal Administration

The Journal of Clinical Pharmacology, 1997
This study aimed to characterize the pharmacokinetics and pharmacodynamics of midazolam after intranasal administration to healthy volunteers. Eight participants were given 0.25 mg/kg intranasally and 2 mg intravenously in a randomized, crossover fashion.
A H, Burstein, R, Modica, M, Hatton, A, Forrest, F M, Gengo   +4 more
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Hydromorphone Transfer into Breast Milk After Intranasal Administration

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2003
Study Objectives . To determine the distribution of hydromorphone into breast milk and the potential exposure of the suckling infant, and whether the distribution of hydromorphone into milk can be predicted accurately by a passive diffusion model. Design
Jeffrey E, Edwards, Anita C, Rudy, Daniel P, Wermeling, Nirmala, Desai, Patrick J, McNamara   +4 more
openaire   +2 more sources

Accidental intranasal administration of phenol.

Veterinary and human toxicology, 1999
A 79-y-old man developed erythema and superficial sloughing of the turbinate following accidental intranasal administration of 89.2% phenol solution. Previous documented reports of phenol exposure include exposures via dermal and oral routes, but no reports of nasal phenol administration were found.
L F, Durback-Morris, E J, Scharman
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Intranasal administration of desmopressin acetate (DDAVP) to hemophiliacs

Thrombosis Research, 1980
Abstract The intravenous infusion of desmopressin acetate (DDAVP), a synthetic vasopressin analogue, has been shown to cause a sustained increase in all Factor VIII related properties (VIII-C, VIIIR-Ag, VIIIR-WF) in patients with mild to moderate hemophilia and von Willebrand's disease. This study examines the effect of high doses of intranasal DDAVP
D L, Dewald, B, Briggs, R E, Smith
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Intranasal oxytocin administration is reflected in human saliva

Psychoneuroendocrinology, 2012
Following the discovery that intranasal administration of neuropeptides can reach the central nervous system, a growing number of studies applied intranasal oxytocin (OT) paradigms to demonstrate the positive effects of OT on social and emotional processes.
Omri, Weisman, Orna, Zagoory-Sharon, Ruth, Feldman   +2 more
openaire   +2 more sources