Results 291 to 300 of about 96,743 (331)

Intranasal administration of melatonin starch microspheres

International Journal of Pharmaceutics, 2004
Using melatonin as model drug, starch microspheres for intranasal administration were prepared by an emulsification-crosslinking technique using a uniform design to optimize preparation conditions. The entrapment ratio of melatonin in the microspheres was 11.0% and particle sizes ranged from 30 to 60 microm. Melatonin was released from the microspheres
Shirui, Mao, Jianming, Chen, Zhenping, Wei, Huan, Liu, Dianzhou, Bi   +4 more
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Intranasal Administration of Influenza Vaccines

BioDrugs, 2000
AbstractThis review article focuses on intranasal immunisation against influenza,although it also encompasses antigen uptake and processing in the nasopharyngealpassages, host defence from influenza and current influenza vaccination practices.Improvement of current vaccination strategies is clearly required; current proceduresinvolve repeated annual ...
J E, Eyles, E D, Williamson, H O, Alpar
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Intranasal estradiol administration to oophorectomized women

European Journal of Obstetrics & Gynecology and Reproductive Biology, 1991
An open, dose-finding study into the effects of a new intranasal 17 beta-estradiol formulation using dimethyl-beta-cyclodextrin as a solubilizer was conducted in nine hysterectomized and oophorectomized patients with symptoms of estrogen deficiency. After nasal delivery of 0.34 mg estradiol in three patients, concentration-time curves of estradiol in ...
W A, Hermens, C W, Belder, J M, Merkus, P M, Hooymans, J, Verhoef, F W, Merkus   +5 more
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Intranasal Administration

Journal of the American College of Toxicology, 1994
The intranasal route has gained increased popularity in the pharmaceutical industry in recent years, particularly because of the number of new peptide therapeutic agents. This has led to a corresponding increase in both interest in and performance of toxicity (or as they are called in the pharmaceutical industry, safety assessment) studies by this ...
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Concentrated Midazolam for Intranasal Administration

Pediatric Emergency Care, 2011
N ...
Calligaris, Lorenzo, Davide, Zanon, Alessandra, Maestro, DE BORTOLI, ROMINA, Chiaretti, Antonio, Barbi, Egidio   +5 more
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Brain distribution of ribavirin after intranasal administration

Antiviral Research, 2011
Ribavirin has proved to be effective in vitro against several RNA viruses responsible for encephalitis in humans and animals. However, the in vivo efficacy towards the cerebral viral load seems to be limited by the blood-brain barrier. Since the nose-to-brain pathway has been indicated for delivering drugs to the brain, we investigated here the ...
Colombo G., LORENZINI, LUCA, ZIRONI, ELISA, GALLIGIONI, VIOLA, Sonvico F., Balducci A.G., PAGLIUCA, GIAMPIERO, GIULIANI, ALESSANDRO, CALZA', LAURA, SCAGLIARINI, ALESSANDRA   +9 more
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Salivary vasopressin increases following intranasal oxytocin administration

Peptides, 2013
Extant research has documented the effects of intranasal administration of oxytocin (OT), and to a lesser degree Arginine Vasopressin (AVP) - two structurally-related neuropeptides - on brain and behaviour, yet the effects of exogenous manipulation of one on circulating levels of the other remain unknown.
Omri, Weisman, Inna, Schneiderman, Orna, Zagoory-Sharon, Ruth, Feldman   +3 more
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Pharmacokinetics and Pharmacodynamics of Midazolam After Intranasal Administration

The Journal of Clinical Pharmacology, 1997
This study aimed to characterize the pharmacokinetics and pharmacodynamics of midazolam after intranasal administration to healthy volunteers. Eight participants were given 0.25 mg/kg intranasally and 2 mg intravenously in a randomized, crossover fashion.
A H, Burstein, R, Modica, M, Hatton, A, Forrest, F M, Gengo   +4 more
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Hydromorphone Transfer into Breast Milk After Intranasal Administration

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2003
Study Objectives . To determine the distribution of hydromorphone into breast milk and the potential exposure of the suckling infant, and whether the distribution of hydromorphone into milk can be predicted accurately by a passive diffusion model. Design
Jeffrey E, Edwards, Anita C, Rudy, Daniel P, Wermeling, Nirmala, Desai, Patrick J, McNamara   +4 more
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Accidental intranasal administration of phenol.

Veterinary and human toxicology, 1999
A 79-y-old man developed erythema and superficial sloughing of the turbinate following accidental intranasal administration of 89.2% phenol solution. Previous documented reports of phenol exposure include exposures via dermal and oral routes, but no reports of nasal phenol administration were found.
L F, Durback-Morris, E J, Scharman
openaire   +1 more source