Results 161 to 170 of about 9,279 (208)
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Efficacy of Intravaginal and Intranasal Administration of Micronized Estradiol-17β1
The Journal of Clinical Endocrinology & Metabolism, 1977Absorption of micronized 17beta-estradiol (E2), after intravaginal administration of 1 mg dose, suspended in saline, is extremely rapid and sustained. A mean peak increment of circulating E2 concentrations of more than 110 times the basal level is achieved at 2 h and remains elevated more than 6 times the basal level even at 24 h. Increments in estrone
B. Villanueva +3 more
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Abortion of early pregnancy by the intravaginal administration of prostaglandin F2α
American Journal of Obstetrics and Gynecology, 1973Abstract Intravaginal prostaglandin F 2α (PGF 2α ) as an aqueous Tham salt solution was evaluated as a method for abortion of early gestations. Two drug concentrations were studied. All 4 patients treated with a 50 mg. per milliliter solution failed to abort and required dilatation and suction evacuation. Six of 8 gravidas treated with a 200 mg.
Stephen L. Corson, Ronald J. Bolognese
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Intravaginal administration of progesterone: enhanced absorption after estrogen treatment
Fertility and Sterility, 1981A progesterone solution was administered by intravaginal instillation, intramuscular injection, and sublingually to estrogen-deficient women, with or without estradiol (E2) replacement, and serum progesterone (P) concentrations were measured by radioimmunoassay. Intravaginal application to postmenopausal subjects receiving E2 gave the highest values of
Robert F. Casper +2 more
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Intravaginal oestrogen and progestin administration: advantages and disadvantages
Best Practice & Research Clinical Obstetrics & Gynaecology, 2008The vagina provides a local and a systemic route for delivering hormones for systemic effects and uterine targeting. Due to the 'uterine first-pass effect', hormones concentrate in the uterus and nearby tissues with low systemic exposure. Vaginal oestrogens, progesterone/progestins and danazol are currently used to obtain local (vagina and urethra ...
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Journal of Pharmaceutical Sciences, 1982
The technical feasibility of utilizing tampons as a drug delivery system for prolonged intravaginal drug administrations was studied. Several commercially available brands of tampons were examined. The methodology for the incorporation of various doses of metronidazole, an antitrichomonas agent, in tampons was described.
Y.W. Chien +3 more
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The technical feasibility of utilizing tampons as a drug delivery system for prolonged intravaginal drug administrations was studied. Several commercially available brands of tampons were examined. The methodology for the incorporation of various doses of metronidazole, an antitrichomonas agent, in tampons was described.
Y.W. Chien +3 more
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Radioimmunoassay of serum d-norgestrel in women following oral and intravaginal administration
Contraception, 1975A radioimmunoassay (RIA) method for measuring d-Norgestrel (d-Ng) in serum has been developed utilizing petroleum ether extraction, an antiserum raised against d-Norgestrel3-(O-carboxymethyl) oxime-e-aminocaproic acid — bovine serum albumin, d-Norgestrel-3-(O-carboxymethyl) imino- [125I]-iodohistamine, and dextran-coated charcoal separation.
Masahiko Hiroi +5 more
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Intravaginal administration of RU 486 in humans and rats: inadequate absorption in humans
Human Reproduction, 1987Vaginal absorption of the antiprogesterone steroid RU 486 was studied in humans and rats. In rats, RU 486 was sufficiently absorbed to terminate early pregnancy following vaginal, oral or intramuscular administration. The quantitation of RU 486 in serum showed that the ratios of the areas under the concentration curves per mg administered were 1:2.8:3 ...
Ana Maria Salvatierra +5 more
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Serum steroid levels during 12-week intravaginal dehydroepiandrosterone administration
Menopause, 2009Because a previous 1-week study has shown no or minimal changes in the serum levels of dehydroepiandrosterone (DHEA) and its metabolites after up to daily 1.8% (23.4 mg) intravaginal DHEA, the objective of the present study was to investigate the serum steroid levels during a 12-week daily intravaginal administration of 0%, 0.25%, 0.5%, and 1.0% DHEA ...
Claude Labrie +19 more
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Mid-trimester abortion induced by intravaginal administration of prostaglandin E2 suppositories
American Journal of Obstetrics and Gynecology, 1975Mid-trimester abortion was successfully induced in 70 of 71 patients by administration of vaginal PGE2 suppositories. The one patient who failed to abort with this method was pregnant in the blind horn of a duplex uterus. The mean abortion time for the successful inductions was 11.88 hours.
Niels J. Secher +2 more
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Journal of Endocrinology, 1954
SUMMARY From the results of two successive intravaginal tests with oestrone, mice were classified into groups having different sensitivities. These groups were more homogeneous in their responses than the parent colony, and hence the slope of the within-group dose-response lines was increased.
C. W. Emmens +2 more
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SUMMARY From the results of two successive intravaginal tests with oestrone, mice were classified into groups having different sensitivities. These groups were more homogeneous in their responses than the parent colony, and hence the slope of the within-group dose-response lines was increased.
C. W. Emmens +2 more
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