Results 11 to 20 of about 34,804 (275)

Sublingual Administration of Drugs [PDF]

Anesthesiology, 1944
In discussions of therapeutic technics there is frequently recurring opinion to the effect that any of the potent nonirritant drugs may be effectively administered by simple application to the oral mucosa. 1 Very few drugs, however, are routinely used in this way in regular practice.
openaire   +2 more sources

Pharmacokinetics of repeated doses of misoprostol [PDF]

, 2009
BACKGROUNDMisoprostol is widely used in obstetrics and gynaecology for medical abortion, cervical priming and induction of labour. To aid the design of effective and safe regimens, we have investigated the pharmacokinetic parameters after the vaginal or ...
Ho, PC, Lee, SWH, Schweer, H, Tang, OS
core   +1 more source

Sublingual Administration of Heparin

Experimental Biology and Medicine, 1951
ConclusionSodium heparin is a practical and effective anticoagulant when administered sublingually. By this method, the coagulation time of the blood was consistently prolonged to the therapeutically effective levels for 4 hr.
J, LITWINS, J J, VORZIMER, L N, SUSSMAN, N, APPLEZWEIG, A D, ETESS   +4 more
openaire   +2 more sources

Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson’s disease

Clinical and Translational Science, 2021
Apomorphine is an on‐demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD). A joint parent‐metabolite population pharmacokinetic (PK) model characterized apomorphine and apomorphine‐sulfate following administration of apomorphine ...
Felix Agbo, Ryan L. Crass, Yu‐Yuan Chiu, Sunny Chapel, Gerald Galluppi, David Blum, Bradford Navia   +6 more
doaj   +1 more source

Selective review and commentary on emerging pharmacotherapies for opioid addiction. [PDF]

, 2011
Pharmacotherapies for opioid addiction under active development in the US include lofexidine (primarily for managing withdrawal symptoms) and Probuphine®, a distinctive mode of delivering buprenorphine for six months, thus relieving patients, clinicians,
Ling, Walter, Miotto, Karen, Mooney, Larissa, Nielsen, Suzanne, Torrington, Matthew, Zhao, Min   +5 more
core   +2 more sources

Pharmacokinetics and pharmacodynamics of propranolol in hypertensive patients after sublingual administration: systemic availability

Brazilian Journal of Medical and Biological Research, 1998
The bioavailability of propranolol depends on the degree of liver metabolism. Orally but not intravenously administered propranolol is heavily metabolized.
A.P. Mansur, S.D. Avakian, R.S. Paula, H. Donzella, S.R.C.J. Santos, J.A.F. Ramires   +5 more
doaj   +1 more source

Sublingual Nitroglycerin Administration to Relieve Radial Artery Vasospasm and Retrieve Wedged Catheter: A Consideration in Neuroangiography

Stroke: Vascular and Interventional Neurology, 2022
Background Radial artery spasm is a common hinderance during transradial approaches for neuroangiography. Ways of alleviation have been described, including patient sedation, local lidocaine, or even prophylactic administration of intra‐arterial ...
Asad S. Akhter, Richard Gumina, Shahid Nimjee   +2 more
doaj   +1 more source

Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]

, 2019
Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair, Alhayali, Allam, Alonzo, Boateng, Brady, Brouwers, Campisi, Chapple, Curatolo, De Caro, El-Setouhy, ElMeshad, Gao, Garsuch, Gittings, Guo, Hanif, Hobbs, Huang, Humphrey, Jug, Kalia, Kapoor, Kim, Koland, Korhonen, Li, Liew, Madhav, Mashru, Matsubara, Miller-Chou, Montorsi, Nagy, Patel, Prabhu, Prasad, Preis, Preis, Preis, Radebaugh, Repka, Rossi, Runja, Sharma, Singh, Singh, Singh, Singh, Slavkova, Tanno, Vila, Visser, Vuddanda, Vuddanda, Yang, Zhang   +57 more
core   +2 more sources

Sublingual administration of liposomes enclosing alpha-galactosylceramide as an effective adjuvant of allergen immunotherapy in a murine model of allergic rhinitis

Allergology International, 2019
Background: Sublingual immunotherapy (SLIT) is an established efficacious approach for the treatment of allergic rhinitis (AR). However, SLIT requires a long administration period to establish stable and adequate responses.
Satoshi Suzuki, Daiju Sakurai, Toshioki Sakurai, Syuji Yonekura, Tomohisa Iinuma, Yusuke Okuma, Fumie Ihara, Tomoyuki Arai, Toyoyuki Hanazawa, Emi Fukuda-Kawaguchi, Yasuyuki Ishii, Yoshitaka Okamoto   +11 more
doaj   +1 more source

Mucosal Application of gp140 Encoding DNA Polyplexes to Different Tissues Results in Altered Immunological Outcomes in Mice [PDF]

, 2013
Increasing evidence suggests that mucosally targeted vaccines will enhance local humoral and cellular responses whilst still eliciting systemic immunity.
A Azizi, A Kantele, A Minne, BA Koblin, C Lindholm, CJ Wei, CM Rush, DL Woodland, H Jiang, J De Calisto, J Holmgren, Jamie F. S. Mann, JF Mann, JF Richmond, JH Song, John S. Tregoning, John Stambas, JR Mora, L Buonaguro, L Torrieri-Dramard, L Wu, LS Klavinskis, M Bivas-Benita, MA Arias, MR Neutra, Paul F. McKay, R Geiben-Lynn, Reeyeshkumar K. Patel, Robin J. Shattock, S Lu, S Mazumder, S Wang, Samantha Arokiasamy, SW Barnett, XD Yao, Z Wang   +35 more
core   +4 more sources