Results 111 to 120 of about 3,501,089 (247)

Preliminary insights into intratesticular and intraepididymal administration of eugenol: histological alterations and impact on sperm motility in Wistar rats. [PDF]

Anim Reprod
Carvalho RPR, Ribeiro IM, Ramirez-Lopez C, da Silva TB, de Sousa AFR, de Azevedo Viana AG, de Medeiros V, Trindade ACM, Ferreira TRM, Ervilha LOG, Machado-Neves M.   +10 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Metformin Regulation of the Liver Circadian Clock and Metabolic Aging: A Systems Modeling Study. [PDF]

Metabolites
Zhang M, Li Y.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Systemic microbial antigen administration ameliorates experimental autoimmune encephalomyelitis via MHC-II downregulation in the CNS and secondary lymphoid organs. [PDF]

J Neuropathol Exp Neurol
Boziki M, Theotokis P, Kesidou E, Karafoulidou E, Salamotas I, Chatziefstratiadou A, Touloumi O, Papadakos K, Sgouras D, Einstein O, Kountouras J, Grigoriadis N.   +11 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Therapeutic Effects of Single and Combined Anti-Disseminated Intravascular Coagulation (DIC) Drugs in a Rat Venom-Induced Consumption Coagulopathy (VICC) Model Using Yamakagashi (<i>Rhabdophis tigrinus</i>) Venom. [PDF]

Toxins (Basel)
Yamamoto A, Ito T, Hifumi T.
europepmc   +1 more source

HOSPITAL ADMINISTRATION [PDF]

AJN, American Journal of Nursing, 1923
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of olopatadine hydrochloride on substance P concentrations in nasal secretions and nasal symptoms. [PDF]

World J Exp Med
Katagiri F, Hatoyama-Tanaka S, Watanabe T, Takayanagi R, Suzuki M, Yamada Y.   +5 more
europepmc   +1 more source