Results 81 to 90 of about 7,880,769 (355)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Business Incubators in Brazil: Main Gaps to Be Explored by Academic Researchers

open access: yesJournal of Technology Management & Innovation, 2015
The business incubators have an essential role at any global entrepreneurial ecosystem. Through the support offered to entrepreneurs in terms of infrastructure and management, they reduce mortality risk of startup companies and contribute to better ...
Gustavo Tietz   +3 more
doaj   +1 more source

Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities

open access: yesBioDrugs, 2018
Subcutaneous delivery of biotherapeutics has become a valuable alternative to intravenous administration across many disease areas. Although the pharmacokinetic profiles of subcutaneous and intravenous formulations differ, subcutaneous administration has
B. Bittner, W. Richter, Johannes Schmidt
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

The Typology of Administration Systems in the Management of Enterprises in View of the European Integration Processes [PDF]

open access: yesBìznes Inform, 2018
The article evolves the typology of administration systems in the management of enterprises in view of the European integration processes, providing systematization of their kinds by the number of existing (content, space-time characteristic ...
Ovcharuk Vadym V.
doaj  

Health benefits of resveratrol administration.

open access: yesActa Biochimica Polonica, 2019
Resveratrol is a polyphenol that is abundant in grape skin and seeds. Food sources of resveratrol include wine, berries, and peanuts. This compound has many properties, including activity against glycation, oxidative stress, inflammation ...
Sabina Galiniak   +2 more
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

From On-Campus to Online: A Trajectory of Innovation, Internationalization and Inclusion

open access: yesInternational Review of Research in Open and Distributed Learning, 2016
This paper presents a study focused on a trajectory for developing an online operating mode on a campus-based university in the area of Massachusetts, USA.
Darlinda Pacheco Moreira
doaj   +1 more source

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