Results 81 to 90 of about 9,194,937 (294)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

DEVELOPMENT PERSPECTIVES FOR THE SMES IN BIHOR COUNTY [PDF]

open access: yes
By its nature, the SMEs sector is flexible having a great capacity to adapt to the changes occurring on the market. Due to this reason, for most European countries, the SMEs sector has been and still is very carefully treated.
Ban Olimpia
core  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

PROGNOSIS OF MONTHLY UNEMPLOYMENT RATE IN THE EUROPEAN UNION THROUGH METHODS BASED ON ECONOMETRIC MODELS [PDF]

open access: yes
In this paper we propose the prognosis of the unemployment rate in the European Union through the Box-Jenkins method and the TRAMO/SEATS method as well as the detection of the method which proves to provide the best results. The monthly unemployment rate
Balan Christiana Brigitte   +1 more
core  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Territorial Reform, Institutional Change and Economic Development. The Regions’ Evolution and their Perspective along the Romanian History

open access: yesEIRP Proceedings, 2012
The present study had as starting point the fact that regionalism has quite a strong tradition inRomania. Ever since the formation of the modern Romanian state the state divisions occurred as solidadministrative units, each of them having its own ...
Monica Boldea   +2 more
doaj  

THE ASPECTS OF OCCUPATIONAL SYSTEM IN ROMANIA FROM DEVELOPMENT OF SERVICES PERSPECTIVE [PDF]

open access: yes
The objective of the paper is to underline the changes in occupational system in Romania, to present an empirical situation on occupied population on groups of occupations, revealing the importance of services sector.
MOISE MIHAELA, NAE TATIANA-ROXANA
core  

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