Results 41 to 50 of about 1,497,472 (306)

On the Proportionality of Measures of Administrative Responsibility to Public Harm Caused by Violations of the Law on Public Procurement

Сибирское юридическое обозрение, 2017
The Authors of the article consider the institution of administrative responsibility as a necessary legal tool for implementing state policy on public procurement issues.
Vladimir V. Kozhevnikov, Yurii B. Lavrov
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The mechanism of administrative and legal regulation of state control over the circulation of narcotic drugs, psychotropic substances and precursors: scientific and theoretical aspects

Проблеми Законності, 2019
The article based on the analysis of scientists' points of view formulated the author’s definition of the legal construction “administrative and legal regulation of state control over the circulation of narcotic drugs, psychotropic substances and ...
Олександр Михайлович Шевчук
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Administrative Acts Completely Removed from the Control of the Legality of the Administrative Contentious Courts

Journal of Danubian Studies and Research, 2022
With the appearance and establishment of the administrative contentious, the issue of the existence of an absolute right of control of the courts over administrative acts arose.
Maria Cristiana Ieremie
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Administrative and Judicial Discretion in Procedural Decision Making under the Code of Administrative Offenses of the Russian Federation

Сибирское юридическое обозрение
This article continues the scholarly discussion initiated by Professors Yu. P. Solovey, P. P. Serkov, and S. A. Starostin on the issue of administrative discretion. Drawing on the theoretical framework proposed by Yu. P.
S. V. Schepalov
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Global administrative law: the key aspects of conceptualizing [PDF]

Lex Portus, 2019
The present article provides the analyses of the main aspects of the global administrative law concept been proposed at the early 2000 to explain legal particulars of the global governance phenomenon.
Borys Kormych
doaj   +1 more source