Results 71 to 80 of about 1,497,472 (306)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Utah Administrative Code 1987-1988, Volume 1
, 1987 Series 83623 | Utah Division of Administrative Rules | Utah Administrative Code | Utah Administrative Code 1987-1988, Volume 1The Utah Administrative Code is the authorized compilation of the administrative law of Utah (See Utah Code Section 63-46a-16 ...
Utah Division of Administrative Rules
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Other title: State of Ohio administrative policy. Major project governance
, 2020 Effective: January 2, 2020"The Department of Administrative Services and the Office of Budget and Management are focused on and committed to improving the overall success rate for enterprise and agency-level technology initiatives by providing standards ...
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On The Issue of the Categorization of Administrative Offences
Сибирское юридическое обозрение, 2019 Some problems of modern administrative-tort and criminal legislation and law are considered. On the positive side, the sequence of the legislator is assessed regarding the delimitation of the norms of criminal and administrative responsibility. Attention
V. I. Surgutskov
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Utah Administrative Code 1987-1988, Volume 3
, 1987 Series 83623 | Utah Division of Administrative Rules | Utah Administrative Code | Utah Administrative Code 1987-1988, Volume 3The Utah Administrative Code is the authorized compilation of the administrative law of Utah (See Utah Code Section 63-46a-16 ...
Utah Division of Administrative Rules
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Barataria, 2016 This article reports findings from a comparative study of the influence of values and norms on the delivery of administrative and professional services in the public sector at the local government level in three selected countries in the Baltic Sea ...
Monica Kjørstad +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Utah Administrative Code 1989, Volume 1
, 1989 Series 83623 | Utah Division of Administrative Rules | Utah Administrative Code | Utah Administrative Code 1989, Volume 1The Utah Administrative Code is the authorized compilation of the administrative law of Utah (See Utah Code Section 63-46a-16 (1987 ...
Utah Division of Administrative Rules
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source