Results 81 to 90 of about 1,125,326 (310)

Brief Amici Curiae of Intellectual Property Professors in Support of Petitoner [PDF]

, 1998
Congress enacted the Administrative Procedure Act (APA) in 1946 as a comprehensive statute to regulate the field of federal administrative law. In holding that the PTO Board of Patent Appeals and Interferences is not subject to the standards of judicial ...
Duffy, John F., Field, Thomas G., Jr., Nard, Craig Allen   +2 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Estudio relativo a los principios de la potestad sancionadora y a la tramitación del nuevo procedimiento sancionador común, a la vista de su regulación en las Leyes 39/2015 y 40/2015 y de la jurisprudencia reciente

Revista Vasca de Administración Pública, 2018
After more than one year after the entry into force of the Laws 39/2015 of the common administrative procedure of the Public Administrations and 40/2015 of legal regime of the public sector, the personnel of the Public Administrations have had ...
Sonia Gavieiro González
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Administrative contracts according to the General Administrative Procedure Act [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2017
In 2016 the Republic of Serbia passed the new General Administrative Procedure Act, which regulate administrative contract as a new legal institute, with only five articles. The paper presents the problems that brings this way of legal regulation.
Miljić Dražen S.
doaj  

Le devoir d'équité procédurale et le contrôle judiciaire ou quasi judiciaire de la procédure administrative [PDF]

, 1982
The doctrine of « procedural fairness » is widening its scope of application to all kinds of administrative decisions. « Procedure » must, as a notion, therefore be clearly defined. The definitions given by the authors or by case-law make it difficult to
Garant, Patrice
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Problematic issues of administrative procedure recording [PDF]

, 2016
Охарактеризовано суть поняття фіксування адміністративного процесу, способи здійснення, детально розглянуто процес фіксування та проблеми, які виникають на практиці. Розроблено теоретично обґрунтовані рекомендації щодо удосконалення норм чинного Кодексу
Rieznik, Oleh Mykolaiovych, Борсук, С.С., Резник, Олег Николаевич, Рєзнік, Олег Миколайович   +3 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source