Results 111 to 120 of about 6,498,853 (379)
Devolved school-based financial management in New Zealand : observations on the conformity patterns of school organisations to change [PDF]
, 2003 This paper examines the intent and consequences of ‘new’ financial management (the ‘New Public Financial Management’) (NPFM) procedures invoked to facilitate a macro-micro interface within the context of the significant administrative reform of the New ...
Guthrie, J., Tooley, S.
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
ANALYSIS OF THE INVESTMENT CLIMATE OF DENMARK [PDF]
Êvropejsʹkij Vektor Ekonomìčnogo RozvitkuThe investment climate is a key factor for attracting capital, stimulating innovation and strengthening competitiveness. The purpose of the study is to analyze the current state of the investment environment in the country, assess its attractiveness for
Elvina Lymonova, Marina V. Filchenkova
doaj +1 more source
The Arbitration Profession in Transition: Preliminary Results From a Survey of the National Academy of Arbitrators [PDF]
, 2000 [Excerpt} In recent years, there has been a dramatic increase in the arbitration and mediation of employment-related disputes. This increase has been part of a larger shift from reliance on litigation and agency resolution of disputes to the use of ...
Lipsky, David B +2 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
UAPPM Policy 2740: Sexual Misconduct [PDF]
, 2018 The UAPPM policy on Sexual Misconduct, issued in 2015 and revised in 2018, that provides substantial definitions and procedures for dealing with misconduct at the ...
University Administrative Policies and Procedures
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
REFORMING PUBLIC ADMINISTRATION IN THE CONTEXT OF THE EU SERVICES DIRECTIVE IMPLEMENTATION. A CASE STUDY ON THE BUSINESS REGISTRATION PROCESS IN ROMANIA [PDF]
Romania is currently facing a lot of challanges in the public administration (PA) field. In this context probably one of the most pressing factors is the European Union integration process. Thus, starting with 2007, when Romania joined the European Union,
Anca ANDREESCU +5 more
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