Results 91 to 100 of about 407,369 (306)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Administrative Bureaus with Standard Operating Procedures [PDF]

We investigate the terms of exchange between the legislative branch of the government and an administrative bureau with standard operating procedures. An administrative bureau is a not-for-profit public organisation responsible for the production of a ...
Miltos Makris
core  

The Decision-Making Process in Administrative Cases

, 2017
The article investigates the procedural aspect of the administrative proceedings. It showcases current problems as regards the structuring of the administrative-delict process and offers a comparison of some main scientific approaches to the structure of
Gurzhii, Anna; Kyiv National University of Trade and Economics, Commercial Law Department
core   +1 more source

Fundamentals of the administrative decentralization process [PDF]

Annals of the University of Craiova: Economic Sciences Series, 2017
Public administration, as an activity carried out by the administrative authorities, can be achieved through several forms of organization. In this sense, centralization, deconcentration and decentralization, together with its corollary, local autonomy ...
Mihaela Lupăncescu
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

From administrative law to administrative legitimation? Transnational administrative law and the process of European integration

, 2012
Globalization redefines the relationship between law and space, resulting in the emergence of transnational administrative law in a globalizing legal space.
Kuo, Ming-Sung
core   +1 more source

Administrative Delict Proceedings as a Procedural Form of the National System of Justice

Сибирское юридическое обозрение
The article advances the idea that proceedings in cases of administrative offences in courts of general jurisdiction form part of a broader procedural phenomenon that encompasses judicial authorisation of measures of administrative coercion for ...
S. V. Schepalov
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Europeanization or Curricular Harmonization in the Area of Administrative Sciences (Follow-Up of Bologna Process): Comparative Analysis and Empirical Research

The paper aims a comparative analysis of curricula for Bachelor studies in the area of administrative sciences. The objectives of research focused on elaboration of a set of indicators, based on the curricular contents of the programmes from the first ...
Matei, Lucica
core