Results 111 to 120 of about 407,369 (306)
Administrative burdens and dairy industry competitiveness
The goal of this paper is to assess the effect of regulatory burdens in the European dairy industry on its competitiveness. A theoretical foundation is provided by transaction cost economics and total quality management insights.
Poppe, Krijn J. +3 more
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Using worker flows in the analysis of establishment turnover : evidence from German administrative data [PDF]
"Economists have long been interested in the determinants and components of job creation and destruction. In many countries administrative datasets provide an excellent source for detailed analysis on a fine and disaggregate level.
Hethey, Tanja, Schmieder, Johannes F.
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Actio popularis in administrative process
, 2014 Bakalaura darba tēma ir "Populārsūdzība administratīvajā procesā". Populārsūdzība ir nepilnīgi un vispārīgi regulēts, un salīdzinoši jauns tiesību insitūts Latvijas tiesību sistēmā, kas juristu vidū ir raisījis diskusijas.
Oja, Kārlis
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Decentralization Process of Rural Development Policy in Greece [PDF]
The decentralization process of national administrative systems, the continuous evolution of structural policies in the EU and the increasing reinforcement of the second Pillar of the Common Agricultural Policy, create an entirely new setting in the ...
Sofia Hatzipanteli, Pavlos Karanikolas
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