Results 131 to 140 of about 407,369 (306)
Administrative reform and process of Turkey's practise
, 2003 ÖZET Bu çalışmada ülkemiz kamu yönetimini doğrudan ilgilendiren ve etkileyen idari reform süreci ayrıntılı bir şekilde ele alınmıştır. Bu bağlamda önce idari reformun tanımı, kapsamı, gerekleri, süreci ve aşamaları, uygulama alanları gibi konular sonraki
Terzi, Halil
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Data Processing in University Administration [PDF]
The Computer Journal, 1960 P. F. Windley +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Administrative law and administrative process [PDF]
У підручнику розкрито питання Загального адміністративного права, Особливого адміністративного права, Спеціального адміністративного права, Адміністративного судочинства України, Європейського адміністративного права та Адміністративного процесу ЄС.
Нашинець-Наумова, Анфіса Юріївна
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Modelling the process of Health Visiting
, 2007 It is very difficult to get a realistic picture of organizational activity. Yet without such a picture it is well nigh impossible to design Information Technology (IT) systems to properly support the work of the healthcare professional.
Ian Robertson, Informatics Process Group
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source