Results 201 to 210 of about 7,286 (264)

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

Angewandte Chemie, EarlyView.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada, Yin Sun, Toru Sengoku, Hiroaki Suga   +5 more
wiley   +1 more source

Machine‐Learning‐Guided Discovery of Boron‐Free Narrowband Blue Thermally Activated Delayed Fluorescence Emitters

Angewandte Chemie, EarlyView.
A data‐driven discovery engine—exhaustive enumeration of carbazole‐containing polycyclic aromatic hydrocarbons (Cz‐PAHs) followed by machine learning—identifies boron‐free, narrowband blue thermally activated delayed fluorescence emitters for organic light‐emitting diodes (OLEDs).
Masaya Hagai, Jie Sun, Jun Hyeon Lee, Kazuhiro J. Fujimoto, Shigehiro Yamaguchi, Takuma Yasuda, Takeshi Yanai   +6 more
wiley   +1 more source

The impact of legislative regulation on animal epidemic prevention and control input: evidence from 13 main provinces of pig production in China. [PDF]

Front Vet Sci
Liu W, Tao J.
europepmc   +1 more source

Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides

Angewandte Chemie, EarlyView.
Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi, Mariko Akiba, Marin Yokomine, Masatake Sugita, Koji Umezawa, Yuto Hirota, Yutaka Akiyama, Jumpei Morimoto, Shinsuke Sando   +8 more
wiley   +1 more source

Physician peer review: just culture and practical implementation in an emergency department. [PDF]

Int J Emerg Med
Fromm C, Colicino M, Carter MA, Datner EM.   +3 more
europepmc   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +1 more source

Food insecurity and child mental health in Masaka District, Uganda: Qualitative study using a realist thematic analysis. [PDF]

Glob Ment Health (Camb)
Kasujja I, Asiimwe JK, Melgar-Quinonez H, Lund C, Taylor Salisbury T.   +4 more
europepmc   +1 more source

Proton‐Switching Regulates Interfacial Iodine Chemistry for Long‐Life Zinc–Iodine Batteries

Angewandte Chemie, EarlyView.
A proton‐switchable imine‐linked framework is developed to dynamically regulate interfacial iodine chemistry in aqueous Zn–I2 batteries, where reversible protonation/deprotonation switches the host affinity between iodide and polyiodide species. This state‐dependent regulation suppresses shuttle‐induced side reactions while preserving fast iodine redox
Feifei Wang, Guoqin Liu, Yuhang Zhuang, Peng Zhang, Zhengwei Li, Songshan Bi, Ahmad Bagheri, Angelika Wrzesińska‐Lashkova, Neda Kargarfard, Peyman Rostami, Yana Vaynzof, Bernd Plietker, Mingchao Wang, Ali Shaygan Nia, Xinliang Feng   +14 more
wiley   +1 more source

Modeling and simulation of railway safety management with public supervision and dynamic incentives: A four-party evolutionary game and system dynamics approach. [PDF]

PLoS One
Li X, Cao X, Deng J, Li X.
europepmc   +1 more source

Microenvironmental Tuning in Isostructural Conjugated Metal–Organic Frameworks for Superior Photocatalytic H2O2 Generation

Angewandte Chemie, EarlyView.
Two isostructural conjugated‐MOFs (Fe‐Tp and Mn‐Tp) photocatalysts were engineered with nonequivalent microenvironmental redox tuning for hydrogen peroxide production. The manganese analog engages both the oxygen reduction reaction and the water oxidation reaction while suppressing decomposition, delivering 10 487 µmol g−1 h−1 with an apparent quantum ...
Kayaramkodath Chandran Ranjeesh, Avanti Chakraborty, Pilar Pena Sánchez, Jose Ignacio Martinez, Abdul Khayum Mohammed, Nada Elmerhi, Stefano Canossa, Matjaž Finšgar, Felipe Gándara, Pradip Pachfule, Dinesh Shetty   +10 more
wiley   +1 more source