Results 71 to 80 of about 263,460 (307)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Відмінність дисциплінарної відповідальності від інших видів юридичної відповідальності [PDF]

open access: yes, 2015
Kovalenko, K.V. (2015), “Difference of disciplinary liability from other types of legal liability”, [“Vidminnist dystsyplinarnoi vidpovidalnosti vid inshykh vydiv iurydychnoi vidpovidalnosti”], Visnyk Kharkivskoho Natsionalnoho Universytetu Vnutrishnikh ...
Kovalenko, K. V.   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

DISCIPLINAIRIE LIABILITIES OF THE EUROPEAN PUBLIC SERVANTS [PDF]

open access: yes
Work discipline is essential for the proper conduct of business within an organization with implications for productivity and efficiency. Disciplinary liability arises as a direct result of breach of service obligations and rules of behaviour.
Ana-Maria Bercu, Mihaela Tofan
core  

Analisis Tata Cara Pelaksanaan Uang Paksa Dan Sanksi Administratif Di Pengadilan Tata USAha Negara [PDF]

open access: yes, 2016
Indonesia is a country that is based on state law. Then surely the actions of the government should be based on the applicable law. Principles of the State Administration of justice, to put the judicial control in the implementation of good governance a ...
Afriza, R. (Rika)   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Redesigning the Concept of Law Enforcement in Administrative Violations of General Elections in Indonesia

open access: yesYuridika
Trial mechanism as the only procedure in resolving election administrative violations is a mechanism that is not in accordance with the concept of law enforcement in administrative law that uses not only the trial mechanism but also direct sanctions ...
Jamil Jamil   +3 more
doaj   +1 more source

China's intellectual property rights commitments in the WTO: legal and economic implications [PDF]

open access: yes, 2018
This article assesses the compliance of China's domestic laws in the area of intellectual property rights protection with the WTO Agreement on Trade-Related Intellectual Property Rights (TRIPS), which China obliged to accept upon its entrance into the ...
Fojtíková, Lenka
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Maciej Bernatt, Sankcje administracyjne: między efektywnością i proceduralną sprawiedliwością

open access: yesStudia Prawa Publicznego, 2019
Maciej Bernatt, Administrative Sanctions: Between Effi ciency and Procedural Fairness (Sankcje administracyjne: między efektywnością i proceduralną sprawiedliwością), „Review of European Administrative Law” 2016, vol. 9, iss. 1, s.
Lucyna Staniszewska
doaj   +1 more source

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