Results 41 to 50 of about 2,066 (126)
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Alzheimer's disease (AD) exhibits high genetic and clinical heterogeneity that limits therapeutic success. Patient‐derived brain organoids and their extracellular vesicles (EVs) provide physiologically relevant models to study disease mechanisms and individualized drug responses.
Rachel J. Boyd +10 more
wiley +1 more source
Neurobiology of Disease, 2008 Activity-dependent neuroprotective protein (ADNP) is widely distributed in the cytoplasm of neurons and astrocytes of the hippocampus. Kainic acid (KA)-induced seizures increases neuronal nitric oxide synthase (nNOS) in neurons and inducible NOS (iNOS ...
Anna S. Cosgrave +5 more
doaj +1 more source
Behavioral Interventions, Volume 41, Issue 2, April 2026.ABSTRACT Neurodevelopmental disabilities, including autism spectrum disorder, have increased in prevalence, highlighting the need for reliable and valid instruments that guide behavioral interventions. This study reports a comprehensive psychometric evaluation of the Assessment of Basic Language and Learning Skills–Revised (ABLLS‐R) and the Assessment ...
Thomas W. Frazier +5 more
wiley +1 more source
Frontiers in Immunology, 2023 IntroductionNirsevimab is an extended half-life (M252Y/S254T/T256E [YTE]-modified) monoclonal antibody to the pre-fusion conformation of the respiratory syncytial virus (RSV) Fusion protein, with established efficacy in preventing RSV-associated lower ...
Tyler Brady +9 more
doaj +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source
Human Mutation, Volume 2026, Issue 1, 2026.Chromodomain‐helicase‐DNA‐binding protein 4 (CHD4) is a critical ATP‐dependent chromatin remodeler that plays fundamental roles in transcriptional repression, DNA damage repair, and lineage specification, making it indispensable for cardiovascular development and function.
Apolonia Novillo +6 more
wiley +1 more source
International Journal of Genomics, Volume 2026, Issue 1, 2026.Background Epigenetic signature detection (ESD) identifies disease‐associated DNA methylation patterns and offers valuable insights beyond traditional genomic testing. Episignatures are increasingly recognised for their diagnostic potential, particularly in rare and complex disorders where conventional sequencing falls short.
Amy Harte, Preeti Khetarpal
wiley +1 more source
Advanced Science, Volume 12, Issue 46, December 11, 2025.Inspired by evidence triangulation, a new sensitivity method called MR‐DEG is developed, which uses the differentially expressed gene (DEG) results as additional evidence to minimize pleiotropic effects and strengthen Mendelian randomization (MR) causal estimates. Using dynamic single‐cell expression quantitative trait loci (eQTLs) as an example, it is
Jie Zheng +29 more
wiley +1 more source
BMC Medical Genomics, 2021 Background The pathogenesis of germinal center B-cell type diffuse large B-cell lymphoma (GCB-DLBCL) is not fully elucidated. This study aims to explore the regulation of super enhancers (SEs) on GCB-DLBCL by identifying specific SE-target gene.
Xi Li, Yan Duan, Yuxia Hao
doaj +1 more source
Clinical detection of corticobasal syndrome, beyond an “atypical" Alzheimer's
Alzheimer's &Dementia, Volume 21, Issue S3, December 2025.Abstract Corticobasal syndrome (CBS) corresponds to a progressive deterioration of motor and associative cognitive functions that include ideomotor apraxia, astereognosis/loss of graphesthesia, sensory extinction, alien limb in combination with marked asymmetric limb dystonia, rigidity or myoclonus.
Ignacio Flores +3 more
wiley +1 more source