Results 61 to 70 of about 2,066 (126)

ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy case

Acta Neuropathologica Communications
Background Helsmoortel–Van der Aa syndrome is a neurodevelopmental disorder in which patients present with autism, intellectual disability, and frequent extra-neurological features such as feeding and gastrointestinal problems, visual impairments, and ...
Claudio D’Incal, Anke Van Dijck, Joe Ibrahim, Kevin De Man, Lina Bastini, Anthony Konings, Ellen Elinck, Claudia Theys, Illana Gozes, Zlatko Marusic, Mirna Anicic, Jurica Vukovic, Nathalie Van der Aa, Ligia Mateiu, Wim Vanden Berghe, R. Frank Kooy   +15 more
doaj   +1 more source

A guide to selecting high-performing antibodies for ADNP (UniProt ID: Q9H2P0) for use in western blot, immunoprecipitation, and immunofluorescence [version 1; peer review: 2 approved, 1 approved with reservations]

F1000Research
ADNP is a multifunctional protein involved in chromatin remodeling, transcription, and microtubule interaction, playing a critical role in brain development, with mutations linked to ADNP-Related Disorder. Here we have characterized seven ADNP commercial
Carl Laflamme, Vera Ruíz Moleón, Sara González Bolívar, Riham Ayoubi, Charles Alende, Maryam Fotouhi   +5 more
doaj   +1 more source

Aging ADNP syndrome mice exhibit mutation/sex-dependent disruption of motor behavior and circadian rhythmicity

Neurobiology of Disease
Circadian disruption is an early and clinically relevant feature of Alzheimer's disease and related neurodegenerative conditions, yet the molecular determinants underlying its emergence remain incompletely understood.
Artur Galushkin, Eliezer Giladi, Illana Gozes   +2 more
doaj   +1 more source

ACTIVITY-DEPENDENT NEUROPROTECTIVE PROTEIN EXPRESSION IS REGIONALLY UPREGULATED BY MODERATE AEROBIC EXERCISE IN THE RAT BRAIN

European Journal of Histochemistry
Engaging in moderate aerobic exercise has been shown to significantly enhance cognitive performance and support overall brain health. Physical activity promotes adult neurogenesis and increases synaptic plasticity, particularly in brain regions involved
doaj   +1 more source

Transient peripheral blood transcriptomic response to ketamine treatment in children with ADNP syndrome

Translational Psychiatry
Activity-dependent neuroprotective protein (ADNP) syndrome is a rare neurodevelopmental disorder resulting in intellectual disability, developmental delay and autism spectrum disorder (ASD) and is due to mutations in the ADNP gene. Ketamine treatment has
Ariela S. Buxbaum Grice, Laura Sloofman, Tess Levy, Hannah Walker, Gauri Ganesh, Miguel Rodriguez de los Santos, Pardis Amini, Joseph D. Buxbaum, Alexander Kolevzon, Ana Kostic, Michael S. Breen   +10 more
doaj   +1 more source

NAP (davunetide) preferential interaction with dynamic 3-repeat Tau explains differential protection in selected tauopathies.

PLoS ONE, 2019
The microtubule (MT) associated protein Tau is instrumental for the regulation of MT assembly and dynamic instability, orchestrating MT-dependent cellular processes.
Yanina Ivashko-Pachima, Maya Maor-Nof, Illana Gozes   +2 more
doaj   +1 more source

Oral Presentation

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

CoronaVac-induced antibodies that facilitate Fc-mediated neutrophil phagocytosis track with COVID-19 disease resolution

Emerging Microbes and Infections
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants raise concerns about decreased vaccine efficacy, vaccines continue to confer robust protection in humans, implying that immunity beyond neutralization contributes to vaccine ...
Chuang Li, Jie Yu, Rahma Issa, Lili Wang, Mingzhe Ning, Shengxia Yin, Jie Li, Chao Wu, Yuxin Chen   +8 more
doaj   +1 more source

A whole blood assay for antibody dependent phagocytosis of Plasmodium falciparum infected erythrocytes

Communications Medicine
Background Antibodies are used to protect against Plasmodium falciparum malaria. One antibody target, the variant surface antigens, is expressed on infected erythrocytes (IEs). Antibodies to these antigens can either block IE sequestration in the tissues,
Dilini Rathnayake, Wina Hasang, Alexander Macpherson, HongHua Ding, Laurens Manning, Moses Laman, Maria Ome-Kaius, Holger W. Unger, Feiko Ter Kuile, Mwayi Madanitsa, Bruce Wines, P. Mark Hogarth, Elizabeth H. Aitken, Stephen J. Rogerson   +13 more
doaj   +1 more source

<i>ADNP</i>-Related Neurodevelopmental Disorder: The First Turkish Case Series with Novel Variants and Reduced Intrafamilial Penetrance. [PDF]

Diagnostics (Basel)
Kablan A, Sezer A, Deniz A, Taşdelen E, Dinçsoy Bir F, Kolkıran A, Ataseven Kulalı M, Teralı K, Işık E.   +8 more
europepmc   +1 more source