Results 1 to 10 of about 10,673,510 (116)

Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye. [PDF]

Int J Mol Sci, 2022
Vision is one of the dominant senses in humans and eye health is essential to ensure a good quality of life. Therefore, there is an urgent necessity to identify effective therapeutic candidates to reverse the progression of different ocular pathologies.
Maugeri G, D'Amico AG, Magrì B, Musumeci G, D'Agata V.   +4 more
europepmc   +5 more sources

Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism. [PDF]

Clin Epigenetics, 2023
Abstract Background Individuals affected with autism often suffer additional co-morbidities such as intellectual disability. The genes contributing to autism cluster on a relatively limited number of cellular pathways, including chromatin remodeling.
D'Incal CP, Van Rossem KE, De Man K, Konings A, Van Dijck A, Rizzuti L, Vitriolo A, Testa G, Gozes I, Vanden Berghe W, Kooy RF.   +10 more
europepmc   +6 more sources

A frameshift variant in activity-dependent neuroprotective protein (ADNP) causes nucleocytoskeletal alterations in a dizygotic male twin: a case study. [PDF]

Clin Epigenetics
The Helsmoortel-Van der Aa syndrome is an autosomal-dominant neurodevelopment disorder caused by heterozygous de novo variants in the Activity-Dependent Neuroprotective Protein (ADNP) gene, characterized by autism, intellectual disability, dysmorphic facial features, and deficits in multiple organ systems. ADNP is a zinc finger DNA-binding protein that
D'Incal CP, Van Dijck A, Annear DJ, Harutyunyan L, Elinck E, Dingemans AJM, de Vries BBA, Mateiu L, Meuwissen M, Jansen AC, Kooy RF.   +10 more
europepmc   +9 more sources

Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium. [PDF]

Antioxidants (Basel), 2022
The corneal epithelium, the outermost layer of the cornea, acts as a dynamic barrier preventing access to harmful agents into the intraocular space. It is subjected daily to different insults, and ultraviolet B (UV-B) irradiation represents one of the main causes of injury.
Maugeri G, D'Amico AG, Giunta S, Giallongo C, Tibullo D, Bucolo C, Saccone S, Federico C, Scollo D, Longo A, Avitabile T, Musumeci G, D'Agata V.   +12 more
europepmc   +7 more sources

Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium. [PDF]

Int J Mol Sci, 2023
The corneal epithelium, representing the outermost layer of the cornea, acts as a barrier to protect the eye against external insults such as ultraviolet B (UV-B) radiations. The inflammatory response induced by these adverse events can alter the corneal structure, leading to visual impairment.
Maugeri G, D'Amico AG, Magrì B, Giunta S, Musumeci G, Saccone S, Federico C, Scollo D, Longo A, Avitabile T, D'Agata V.   +10 more
europepmc   +5 more sources

Activity-dependent neuroprotective protein (ADNP): from autism to Alzheimer's disease. [PDF]

Springerplus, 2015
We have originally discovered activity-dependent neuroprotective protein (ADNP) as a major regulatory gene, a component of the SWI/SNF chromatin remodeling complex, essential for brain formation. Others found ADNP as a most frequent autism spectrum disorder (ASD)-associated gene.
Gozes I.
europepmc   +4 more sources

Neuropeptide GPCRs in neuroendocrinology: the case of activity-dependent neuroprotective protein (ADNP). [PDF]

Front Endocrinol (Lausanne), 2012
VASOACTIVE INTESTINAL PEPTIDE (VIP): NEUROPROTECTION AND SYNAPSE FORMATION This review is a selected overview of the chosen subject. As, I have recently summarized my work on VIP (Gozes, 2008), I will describe here only selected topics focusing on the GPCR connection of the VIP-regulated protein, activity-dependent neuroprotective protein (ADNP) (Gozes,
Gozes I.
europepmc   +5 more sources

Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer's pathologies. [PDF]

Transl Psychiatry, 2015
Activity-dependent neuroprotective protein (ADNP) is a most frequent autism spectrum disorder (ASD)-associated gene and the only protein significantly decreasing in the serum of Alzheimer's disease (AD) patients. Is ADNP associated with ASD being more prevalent in boys and AD more prevalent in women?
Malishkevich A, Amram N, Hacohen-Kleiman G, Magen I, Giladi E, Gozes I.   +5 more
europepmc   +4 more sources

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice. [PDF]

Neuropsychopharmacology, 2019
Neuroadaptations in the brain reward system caused by excessive alcohol intake, lead to drinking escalation and alcohol use disorder phenotypes. Activity-dependent neuroprotective protein (ADNP) is crucial for brain development, and is implicated in neural plasticity in adulthood.
Ziv Y, Rahamim N, Lezmy N, Even-Chen O, Shaham O, Malishkevich A, Giladi E, Elkon R, Gozes I, Barak S.   +9 more
europepmc   +4 more sources

Novel evolutionary-conserved role for the activity-dependent neuroprotective protein (ADNP) family that is important for erythropoiesis. [PDF]

J Biol Chem, 2012
ADNP is vital for embryonic development. Is this function conserved for the homologous protein ADNP2?Down-regulation/silencing of ADNP or ADNP2 in zebrafish embryos or mouse erythroleukemia cells inhibited erythroid maturation, with ADNP directly associating with the β-globin locus control region.ADNPs are novel molecular regulators of erythropoiesis ...
Dresner E, Malishkevich A, Arviv C, Leibman Barak S, Alon S, Ofir R, Gothilf Y, Gozes I.   +7 more
europepmc   +4 more sources