Results 11 to 20 of about 10,673,510 (116)

Activity-dependent neuroprotective protein (ADNP) derived peptide NAP prevents musculoskeletal abnormalities in ovariectomized mice. [PDF]

Front Neurosci
Estrogen is an essential hormone that critically impacts bodily and brain functions, supporting learning, memory, and motor activities. A decrease in estrogen levels is associated with cognitive decline and motor dysfunction, such as muscle weakness. While conventional hormone replacement treatments (HRT) exist, those have limitations and potentially ...
Guz LS, Galushkin A, Gozes I.
europepmc   +3 more sources

Novel marker for the onset of frontotemporal dementia: early increase in activity-dependent neuroprotective protein (ADNP) in the face of Tau mutation. [PDF]

PLoS One, 2014
Tauopathy, a major pathology in Alzheimer's disease, is also found in ~50% of frontotemporal dementias (FTDs). Tau transcript, a product of a single gene, undergoes alternative splicing to yield 6 protein species, each with either 3 or 4 microtubule binding repeat domains (tau 3R or 4R, associated with dynamic and stable microtubules, respectively ...
Schirer Y, Malishkevich A, Ophir Y, Lewis J, Giladi E, Gozes I.   +5 more
europepmc   +7 more sources

Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis [PDF]

Developmental Biology, 2007
Complete deficiency in activity-dependent neuroprotective protein (ADNP) results in neural tube closure defects and death at days 8.5-9.5 of gestation in the mouse (E8.5-9.5). To elucidate ADNP associated pathways, Affymetrix 22,690-oligonucleotide-based microarrays were used on ADNP knockout and control mouse embryos (E9) separated completely from ...
Mandel, Shmuel, Rechavi, Gideon, Gozes, Illana   +2 more
openaire   +3 more sources

Diminished activity-dependent neuroprotective protein (ADNP) contributes to complement gene elevation in Alzheimer's disease. [PDF]

J Alzheimers Dis
Background Gene dysregulation is one of the key mechanisms that link pathological abnormalities to cognitive impairment in Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. Our transcriptomic analysis of large-scale postmortem AD human prefrontal cortex (PFC) data revealed that complement ...
Ren Y, Saleem K, Patel PJ, Lee YH, Feng J, Yan Z.   +5 more
europepmc   +3 more sources

NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP). [PDF]

CNS Drug Rev, 2005
Activity-dependent neuroprotective protein (ADNP) is essential for brain formation. Peptide activity scanning identified NAP (NAPVSIPQ) as a small active fragment of ADNP that provides neuroprotection at very low concentrations. In cell culture, NAP has demonstrated protection against toxicity associated with the beta-amyloid peptide, N-methyl-D ...
Gozes I, Morimoto BH, Tiong J, Fox A, Sutherland K, Dangoor D, Holser-Cochav M, Vered K, Newton P, Aisen PS, Matsuoka Y, van Dyck CH, Thal L.   +12 more
europepmc   +4 more sources

Loss-of-function of activity-dependent neuroprotective protein (ADNP) by a splice-acceptor site mutation causes Helsmoortel-Van der Aa syndrome. [PDF]

Eur J Hum Genet
Mutations in ADNP result in Helsmoortel-Van der Aa syndrome. Here, we describe the first de novo intronic deletion, affecting the splice-acceptor site of the first coding ADNP exon in a five-year-old girl with developmental delay and autism. Whereas exome sequencing failed to detect the non-coding deletion, genome-wide CpG methylation analysis revealed
D'Incal CP, Annear DJ, Elinck E, van der Smagt JJ, Alders M, Dingemans AJM, Mateiu L, de Vries BBA, Vanden Berghe W, Kooy RF.   +9 more
europepmc   +8 more sources

Preventive, personalized medicine at the level of key regulatory proteins: updates on activity-dependent neuroprotective protein (ADNP) as a case study [PDF]

The EPMA Journal, 2014
Natural ageing, neurodegenerative diseases, acute head (brain) injury and stroke as well as mental disorders are associated with nerve cell damage and death. We have discovered activity-dependent neurotrophic factor (ADNP) that is essential for brain formation, regulating >400 important genes, including the major risk gene for Alzheimer's disease ...
Gozes I.
europepmc   +3 more sources

Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers. [PDF]

J Alzheimers Dis, 2016
Biomarkers for Alzheimer’s disease (AD) are vital for disease detection in the clinical setting. Discovered in our laboratory, activity-dependent neuroprotective protein (ADNP) is essential for brain formation and linked to cognitive functions. Here, we revealed that blood borne expression of ADNP and its paralog ADNP2 is correlated with premorbid ...
Malishkevich A, Marshall GA, Schultz AP, Sperling RA, Aharon-Peretz J, Gozes I.   +5 more
europepmc   +4 more sources

Microbiota changes associated with ADNP deficiencies: rapid indicators for NAP (CP201) treatment of the ADNP syndrome and beyond [PDF]

, 2020
Activity-dependent neuroprotective protein (ADNP) and its protein snippet NAP (drug candidate CP201) regulate synapse formation and cognitive as well as behavioral functions, in part, through microtubule interaction.
Jaljuli, Iman, Giladi, Eliezer, Bereswill, Stefan, Heimesaat, Markus M., Gozes, Illana, Kapitansky, Oxana   +5 more
core   +1 more source

NAP (Davunetide): The Neuroprotective ADNP Drug Candidate Penetrates Cell Nuclei Explaining Pleiotropic Mechanisms

, 2023
(1) Background: Recently, we showed aberrant nuclear/cytoplasmic boundaries/activity-dependent neuroprotective protein (ADNP) distribution in ADNP-mutated cells.
Gidon Karmon, Yanina Ivashko-Pachima, Maram Ganaiem, Nina D. Gildor, Shula Shazman, Illana Gozes   +5 more
core   +1 more source