Homeodomain Proteins Directly Regulate ATM Kinase Activity [PDF]
Cell Reports, 2018 Summary: Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that coordinates the response to DNA double-strand breaks and oxidative stress.
Tanya E. Johnson +8 more
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Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity [PDF]
eLifeHow our brain generates diverse neuron types that assemble into precise neural circuits remains unclear. Using Drosophila lamina neuron types (L1-L5), we show that the primary homeodomain transcription factor (HDTF) brain-specific homeobox (Bsh) is ...
Chundi Xu +4 more
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Regulation of Silk Genes by Hox and Homeodomain Proteins in the Terminal Differentiated Silk Gland of the Silkworm Bombyx mori [PDF]
Journal of Developmental Biology, 2016 The silk gland of the silkworm Bombyx mori is a long tubular organ that is divided into several subparts along its anteroposterior (AP) axis. As a trait of terminal differentiation of the silk gland, several silk protein genes are expressed with unique ...
Shigeharu Takiya +2 more
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Evaluating the role of a novel homeodomain protein in periodontal regenerative therapy: An in-vitro study [PDF]
Journal of Oral Biology and Craniofacial ResearchIntroduction: The goal of periodontal treatment is to halt disease progression and restore the structure and function of damaged periodontal tissues.
Bhavya Shetty +5 more
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Dissecting the homeodomain MAT locus and engineering novel tripolar and bipolar mating systems in Cryptococcus amylolentus [PDF]
mBioSex in fungi is governed by the mating-type (MAT) locus, which exists as a bipolar, pseudobipolar, or tetrapolar system. The significance and impact of MAT on sexual reproduction, however, remain understudied.
Liping Xiong +3 more
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Zinc Finger Homeobox Transcription Factors OsMIF1 and OsMIF2 Regulate Grain Size and Panicle Development in Rice [PDF]
RiceMini zinc finger (MIF) proteins are plant-specific zinc finger-homeodomain (ZF-HD) transcription factors lacking a homeodomain, and its biological functions are critical for normal plant development and the response to environmental stress.
Jinpyo So +4 more
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Deciphering the pathogenicity of three NKX2-1 variants in ultra-severe forms of childhood interstitial lung disease. [PDF]
PLoS ONEIntroductionThe transcription factor NK2 homeobox1 (NKX2-1), associated with brain lung thyroid syndrome, regulates the transcription of surfactant proteins, thyroglobulin (TG) and thyroid peroxidase (TPO).
Yohan David Soreze +12 more
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Frontiers in Cell and Developmental Biology, 2021 Transcription factors (TFs) guide effector proteins like chromatin-modifying or -remodeling enzymes to distinct sites in the genome and thereby fulfill important early steps in translating the genome’s sequence information into the production of proteins
Marina Reichlmeir +2 more
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Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1. [PDF]
PLoS ONE, 2015 The homeodomain transcription factor Hoxa2 interacts with the RING-finger type E3 ubiquitin ligase RCHY1 and induces its proteasomal degradation. In this work, we dissected this non-transcriptional activity of Hoxa2 at the molecular level.
Laure Bridoux +3 more
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Scientific Reports, 2023 HMX3 is a homeodomain protein with essential roles in CNS and ear development. Homeodomains are DNA-binding domains and hence homeodomain-containing proteins are usually assumed to be transcription factors.
William Haws +6 more
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