Results 11 to 20 of about 1,590,984 (213)

Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins [PDF]

, 1995
Cells translate extracellular signals into specific programs of gene expression that reflect their developmental history or identity. We present evidence that one way this interpretation may be performed is by cooperative interactions between serum ...
Grueneberg, D. A., Brennan, K., Simon, K. J., Gilman, M.   +3 more
core   +11 more sources

Homeodomain proteins in development and therapy

Pharmacology & Therapeutics, 1994
Homeobox genes encode transcriptional regulators found in all organisms ranging from yeast to humans. In Drosophila, a specific class of homeobox genes, the homeotic genes, specifies the identity of certain spatial units of development.
Leupin, W., Dorn, A., Affolter, M., Gehring, W. J.   +3 more
core   +3 more sources

Relief of bHD1 autoinhibition and modular coupling support MAT-A pathway activation in Flammulina filiformis [PDF]

Applied Microbiology and Biotechnology
Flammulina filiformis is a commercially important edible mushroom whose sexual compatibility is determined by genes at two unlinked mating-type loci, A and B. However, the molecular basis of MAT-A activation in this species remains unclear.
Jinwei Zhang, Yu Tian, Xuyang Xiang, Qinghao Fan, Ruiying Zhang   +4 more
doaj   +2 more sources

Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox. [PDF]

Int J Mol Sci, 2019
The Drosophila homeodomain-interacting protein kinase (Hipk) is the fly representative of the well-conserved group of HIPKs in vertebrates. It was initially found through its characteristic interactions with homeodomain proteins.
Steinmetz EL, Dewald DN, Luxem N, Walldorf U.   +3 more
europepmc   +2 more sources

Molecular interactions between homeodomain proteins

, 2000
During embryogenesis, patterning is one of the key processes by which the body plan of the embryo becomes established. Patterning of the A-P axis is accomplished by the products of the Hox gene family.
Shanmugam, Kandavel.
core   +2 more sources

Posttranslational Modifications in Conserved Transcription Factors: A Survey of the TALE-Homeodomain Superclass in Human and Mouse

Frontiers in Cell and Developmental Biology, 2021
Transcription factors (TFs) guide effector proteins like chromatin-modifying or -remodeling enzymes to distinct sites in the genome and thereby fulfill important early steps in translating the genome’s sequence information into the production of proteins
Marina Reichlmeir, Lena Elias, Dorothea Schulte   +2 more
doaj   +1 more source

Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1. [PDF]

PLoS ONE, 2015
The homeodomain transcription factor Hoxa2 interacts with the RING-finger type E3 ubiquitin ligase RCHY1 and induces its proteasomal degradation. In this work, we dissected this non-transcriptional activity of Hoxa2 at the molecular level.
Laure Bridoux, Noémie Deneyer, Isabelle Bergiers, René Rezsohazy   +3 more
doaj   +1 more source

Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3

Scientific Reports, 2023
HMX3 is a homeodomain protein with essential roles in CNS and ear development. Homeodomains are DNA-binding domains and hence homeodomain-containing proteins are usually assumed to be transcription factors.
William Haws, Samantha England, Ginny Grieb, Gabriela Susana, Sophie Hernandez, Hunter Mirer, Katharine Lewis   +6 more
doaj   +1 more source

The roles of HD-ZIP proteins in plant abiotic stress tolerance

Frontiers in Plant Science, 2022
Homeodomain leucine zipper (HD-ZIP) proteins are plant-specific transcription factors that contain a homeodomain (HD) and a leucine zipper (LZ) domain.
Yuxia Li, Zongran Yang, Yuanyuan Zhang, Jinjiao Guo, Lili Liu, Chengfeng Wang, Baoshan Wang, Guoliang Han   +7 more
doaj   +1 more source

Single‐cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos

Molecular Systems Biology, 2022
The correct wiring of neuronal circuits is one of the most complex processes in development, since axons form highly specific connections out of a vast number of possibilities. Circuit structure is genetically determined in vertebrates and invertebrates,
Jessica Velten, Xuefan Gao, Patrick Van Nierop y Sanchez, Katrin Domsch, Rashi Agarwal, Lena Bognar, Malte Paulsen, Lars Velten, Ingrid Lohmann   +8 more
doaj   +1 more source