Results 41 to 50 of about 41,966 (223)

Pbx homeodomain proteins pattern both the zebrafish retina and tectum [PDF]

, 2007
Background Pbx genes encode TALE class homeodomain transcription factors that pattern the developing neural tube, pancreas, and blood. Within the hindbrain, Pbx cooperates with Hox proteins to regulate rhombomere segment identity.
Callander, D., Berry, K.M., Wuennenberg-Stapleton, K., Moens, C.B., Koss, R., Ngai, J., Waskiewicz, A.J., Hagey, D.W., Erickson, T., French, C.R., Stout, J.   +10 more
core   +1 more source

Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding. [PDF]

PLoS Genetics, 2012
The homeodomain and adjacent CVC domain in the visual system homeobox (VSX) proteins are conserved from nematodes to humans. Humans with missense mutations in these regions of VSX2 have microphthalmia, suggesting both regions are critical for function ...
Changjiang Zou, Edward M Levine
doaj   +1 more source

Investigation of Interactions between Homeodomain Proteins and DNA [PDF]

, 2022
In this work spectroscopic and transient-kinetic methods were applied to investigate homeodomain-DNA interactions. The analysis of intrinsic fluorescence and circular dichroism spectra of Bicoid (Bcd), Ultrabithorax (Ubx) and Engrailed (En) homeodomains revealed that the binding of either protein to 15 bp oligonucleotides induces changes in structure ...
Vainius, Darius, Neher, Erwin, Georg-August-Universität Göttingen, Lauterborn, Werner   +3 more
openaire   +3 more sources

Expression of a truncated ATHB17 protein in maize increases ear weight at silking. [PDF]

PLoS ONE, 2014
ATHB17 (AT2G01430) is an Arabidopsis gene encoding a member of the α-subclass of the homeodomain leucine zipper class II (HD-Zip II) family of transcription factors.
Elena A Rice, Abha Khandelwal, Robert A Creelman, Cara Griffith, Jeffrey E Ahrens, J Philip Taylor, Lesley R Murphy, Siva Manjunath, Rebecca L Thompson, Matthew J Lingard, Stephanie L Back, Huachun Larue, Bonnie R Brayton, Amanda J Burek, Shiv Tiwari, Luc Adam, James A Morrell, Rico A Caldo, Qing Huai, Jean-Louis K Kouadio, Rosemarie Kuehn, Anagha M Sant, William J Wingbermuehle, Rodrigo Sala, Matt Foster, Josh D Kinser, Radha Mohanty, Dongming Jiang, Todd E Ziegler, Mingya G Huang, Saritha V Kuriakose, Kyle Skottke, Peter P Repetti, T Lynne Reuber, Thomas G Ruff, Marie E Petracek, Paul J Loida   +36 more
doaj   +1 more source

The homeodomain transcription factor Phox2 in the stellate ganglion of the squid Loligo pealei

Biology Open, 2015
Homeodomain transcription factors regulate development of embryos and cellular physiology in adult systems. Paired-type homeodomain genes constitute a subclass that has been particularly implicated in establishment of neuronal identity in the mammalian ...
J. Peter H. Burbach, Anita J. C. G. M. Hellemons, Philip Grant, Harish C. Pant   +3 more
doaj   +1 more source

PHD finger proteins function in plant development and abiotic stress responses: an overview

Frontiers in Plant Science, 2023
The plant homeodomain (PHD) finger with a conserved Cys4-His-Cys3 motif is a common zinc-binding domain, which is widely present in all eukaryotic genomes.
Wenli Quan, Wenli Quan, Zhulong Chan, Piwei Wei, Yahui Mao, Dorothea Bartels, Xun Liu   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1. [PDF]

PLoS ONE, 2013
Hox proteins are conserved homeodomain transcription factors known to be crucial regulators of animal development. As transcription factors, the functions and modes of action (co-factors, target genes) of Hox proteins have been very well studied in a ...
Isabelle Bergiers, Laure Bridoux, Nathan Nguyen, Jean-Claude Twizere, René Rezsöhazy   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins [PDF]

, 1995
Cells translate extracellular signals into specific programs of gene expression that reflect their developmental history or identity. We present evidence that one way this interpretation may be performed is by cooperative interactions between serum ...
Grueneberg, D. A., Brennan, K., Simon, K. J., Gilman, M.   +3 more
core   +4 more sources