Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding. [PDF]
PLoS Genetics, 2012 The homeodomain and adjacent CVC domain in the visual system homeobox (VSX) proteins are conserved from nematodes to humans. Humans with missense mutations in these regions of VSX2 have microphthalmia, suggesting both regions are critical for function ...
Changjiang Zou, Edward M Levine
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Investigation of Interactions between Homeodomain Proteins and DNA [PDF]
, 2022 In this work spectroscopic and transient-kinetic methods were applied to investigate homeodomain-DNA interactions. The analysis of intrinsic fluorescence and circular dichroism spectra of Bicoid (Bcd), Ultrabithorax (Ubx) and Engrailed (En) homeodomains revealed that the binding of either protein to 15 bp oligonucleotides induces changes in structure ...
Vainius, Darius +3 more
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The homeodomain transcription factor Phox2 in the stellate ganglion of the squid Loligo pealei
Biology Open, 2015 Homeodomain transcription factors regulate development of embryos and cellular physiology in adult systems. Paired-type homeodomain genes constitute a subclass that has been particularly implicated in establishment of neuronal identity in the mammalian ...
J. Peter H. Burbach +3 more
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Expression of a truncated ATHB17 protein in maize increases ear weight at silking. [PDF]
PLoS ONE, 2014 ATHB17 (AT2G01430) is an Arabidopsis gene encoding a member of the α-subclass of the homeodomain leucine zipper class II (HD-Zip II) family of transcription factors.
Elena A Rice +36 more
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C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis [PDF]
, 2006 Within a cell, the levels and activity of multiple pro- and anti-apoptotic molecules act in concert to regulate commitment to apoptosis. Whilst the balance between survival and death can be tipped by the effects of single molecules, cellular apoptosis ...
Blaydes, J.P. +3 more
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Cellular and Molecular Mechanisms regulating Cell Proliferation during the Forebrain Development of the Mouse [PDF]
, 2005 The predominant precursor cell type during cortical neurogenesis are radial glia cells, which receive extrinsic and intrinsic signals that might influence cell proliferation and neurogenesis.
Haubst, Nicole
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PHD finger proteins function in plant development and abiotic stress responses: an overview
Frontiers in Plant Science, 2023 The plant homeodomain (PHD) finger with a conserved Cys4-His-Cys3 motif is a common zinc-binding domain, which is widely present in all eukaryotic genomes.
Wenli Quan +6 more
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Advanced Science, EarlyView.HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun +12 more
wiley +1 more source
Pbx homeodomain proteins pattern both the zebrafish retina and tectum
, 2007 Background Pbx genes encode TALE class homeodomain transcription factors that pattern the developing neural tube, pancreas, and blood. Within the hindbrain, Pbx cooperates with Hox proteins to regulate rhombomere segment identity.
Callander, D. +10 more
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RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites
Advanced Science, EarlyView.At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo +10 more
wiley +1 more source