Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development
eLife, 2018 The ancient mechanisms that caused developmental gene regulatory networks to diversify among distantly related taxa are not well understood. Here we use ancestral protein reconstruction, biochemical experiments, and developmental assays of transgenic ...
Qinwen Liu +7 more
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Improving Hox protein classification across the major model organisms.
PLoS ONE, 2010 The family of Hox-proteins has been a major focus of research for over 30 years. Hox-proteins are crucial to the correct development of bilateral organisms, however, some uncertainty remains as to which Hox-proteins are functionally equivalent across ...
Stefanie D Hueber +3 more
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A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins [PDF]
, 2005 The organization of living cells is based on networks of interacting molecules. Systematic analysis of protein interactions of 3-aa loop extension (TALE) homeodomain proteins, fundamental regulators of plant meristem function and leaf development ...
Uhrig, J. +9 more
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Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor [PDF]
, 1992 Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity.
Gilman, M. Z. +3 more
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Proximity labeling identifies a repertoire of site-specific R-loop modulators
Nature Communications, 2022 R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan +6 more
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A look at life from the homeodomain [PDF]
The EMBO Reports, 2006 ThisThis workshop brought together developmental biologists and oncologists for three intense days of discussions about the recent progress that has been made on the roles of homeodomain proteins in development, haematopoiesis and leukaemogenesis.
Moisés, Mallo, Maria Cristina, Magli
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Homeodomain-interacting Protein Kinases, a Novel Family of Co-repressors for Homeodomain Transcription Factors [PDF]
Journal of Biological Chemistry, 1998 A novel family of cofactors that differentially interact with homeoproteins have been identified via a yeast two-hybrid screen. The proteins contain a conserved protein kinase domain that is separated from a domain that interacts with homeoproteins and hence are termed homeodomain-interacting protein kinases (HIPKs): HIPK1, HIPK2, and HIPK3.
Y H, Kim +4 more
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Characterization of a novel class of plant homeodomain proteins that bind to the C4 phosphoenolpyruvate carboxylase gene of Flaveria trinervia [PDF]
, 2001 We are interested in the regulatory mechanisms responsible for the mesophyll-specific expression of C4 phosphoenolpyruvate carboxylase (PEPCase). A one-hybrid screen resulted in the cloning of four different members of a novel class of plant homeodomain ...
Dabrowa, Rafael +3 more
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Molecular and cellular mechanisms of adipogenesis
Сахарный диабет, 2015 The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue.
Alexander Dmitrievich Egorov +2 more
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A role for heterodimerization in nuclear localization of a homeodomain protein [PDF]
Proceedings of the National Academy of Sciences, 1998 TheAmating type genes of the mushroomCoprinus cinereusencode two families of dissimilar homeodomain proteins (HD1 and HD2). The proteins heterodimerize when mating cells fuse to generate a transcriptional regulator that promotes expression of genes required for early steps in sexual development. In previous work we showed that heterodimerization brings
A, Spit +3 more
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