Results 31 to 40 of about 1,590,984 (213)

An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression

Nature Communications, 2022
Vascular addressins control lymphocyte homing, thus regulating immunity and inflammation, but how addressin expression is patterned remains unknown.
Thanh Theresa Dinh, Menglan Xiang, Anusha Rajaraman, Yongzhi Wang, Nicole Salazar, Yu Zhu, Walter Roper, Siyeon Rhee, Kevin Brulois, Ed O’Hara, Helena Kiefel, Truc M. Dinh, Yuhan Bi, Dalila Gonzalez, Evan P. Bao, Kristy Red-Horse, Peter Balogh, Fanni Gábris, Balázs Gaszner, Gergely Berta, Junliang Pan, Eugene C. Butcher   +21 more
doaj   +1 more source

Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development

eLife, 2018
The ancient mechanisms that caused developmental gene regulatory networks to diversify among distantly related taxa are not well understood. Here we use ancestral protein reconstruction, biochemical experiments, and developmental assays of transgenic ...
Qinwen Liu, Pinar Onal, Rhea R Datta, Julia M Rogers, Urs Schmidt-Ott, Martha L Bulyk, Stephen Small, Joseph W Thornton   +7 more
doaj   +1 more source

Improving Hox protein classification across the major model organisms.

PLoS ONE, 2010
The family of Hox-proteins has been a major focus of research for over 30 years. Hox-proteins are crucial to the correct development of bilateral organisms, however, some uncertainty remains as to which Hox-proteins are functionally equivalent across ...
Stefanie D Hueber, Georg F Weiller, Michael A Djordjevic, Tancred Frickey   +3 more
doaj   +1 more source

Proximity labeling identifies a repertoire of site-specific R-loop modulators

Nature Communications, 2022
R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan, Phillip Wulfridge, John Doherty, Jose L. Fernandez-Luna, Pedro J. Real, Hsin-Yao Tang, Kavitha Sarma   +6 more
doaj   +1 more source

In planta localisation patterns of MADS domain proteins during floral development in Arabidopsis thaliana [PDF]

, 2009
Background: MADS domain transcription factors play important roles in various developmental processes in flowering plants. Members of this family play a prominent role in the transition to flowering and the specification of floral organ identity. Several
Angenent, G.C., Folter, S., de, Urbanus, S.L., Immink, G.H., Kaufmann, K., de Folter, S., Shchennikova, A.   +6 more
core   +1 more source

A look at life from the homeodomain [PDF]

The EMBO Reports, 2006
​ThisThis workshop brought together developmental biologists and oncologists for three intense days of discussions about the recent progress that has been made on the roles of homeodomain proteins in development, haematopoiesis and leukaemogenesis.
Moisés, Mallo, Maria Cristina, Magli
openaire   +2 more sources

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +2 more sources

Molecular and cellular mechanisms of adipogenesis

Сахарный диабет, 2015
The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue.
Alexander Dmitrievich Egorov, Dmitry Nikolaevich Penkov, Vsevolod Arsen'evich Tkachuk   +2 more
doaj   +1 more source

Homeodomain-interacting Protein Kinases, a Novel Family of Co-repressors for Homeodomain Transcription Factors [PDF]

Journal of Biological Chemistry, 1998
A novel family of cofactors that differentially interact with homeoproteins have been identified via a yeast two-hybrid screen. The proteins contain a conserved protein kinase domain that is separated from a domain that interacts with homeoproteins and hence are termed homeodomain-interacting protein kinases (HIPKs): HIPK1, HIPK2, and HIPK3.
Y H, Kim, C Y, Choi, S J, Lee, M A, Conti, Y, Kim   +4 more
openaire   +2 more sources

A role for heterodimerization in nuclear localization of a homeodomain protein [PDF]

Proceedings of the National Academy of Sciences, 1998
The A mating type genes of the mushroom Coprinus cinereus encode two families of dissimilar homeodomain proteins (HD1 and HD2). The proteins heterodimerize when mating cells fuse to generate a transcriptional regulator that promotes expression of genes ...
A, Spit, R H, Hyland, E J, Mellor, L A, Casselton   +3 more
openaire   +2 more sources