Results 21 to 30 of about 41,966 (223)

Single‐cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos

Molecular Systems Biology, 2022
The correct wiring of neuronal circuits is one of the most complex processes in development, since axons form highly specific connections out of a vast number of possibilities. Circuit structure is genetically determined in vertebrates and invertebrates,
Jessica Velten, Xuefan Gao, Patrick Van Nierop y Sanchez, Katrin Domsch, Rashi Agarwal, Lena Bognar, Malte Paulsen, Lars Velten, Ingrid Lohmann   +8 more
doaj   +1 more source

Unconventional Secretion, Gate to Homeoprotein Intercellular Transfer

Frontiers in Cell and Developmental Biology, 2022
Unconventional secretion allows for the secretion of fully mature and biologically active proteins mostly present in the cytoplasm or nucleus. Besides extra vesicle-driven secretion, non-extravesicular pathways also exist that specifically rely on the ...
Alain Joliot, Alain Prochiantz
doaj   +1 more source

HOPX: The Unusual Homeodomain-Containing Protein [PDF]

Journal of Investigative Dermatology, 2016
The homeodomain-only protein homeobox (HOPX) is the smallest known member of the homeodomain-containing protein family, atypically unable to bind DNA. HOPX is widely expressed in diverse tissues, where it is critically involved in the regulation of proliferation and differentiation.
Mariotto A, Pavlova O, Park HS, Huber M, Hohl D   +4 more
openaire   +3 more sources

Functional Interaction of Jun and Homeodomain Proteins [PDF]

Journal of Biological Chemistry, 2001
We have used the yeast two-hybrid system to identify proteins that interact with the N-terminal region of c-Jun, which is known to be involved in regulatory interactions. One of the proteins identified is the homeodomain-containing protein Hex. The Hex homeodomain is sufficient for interaction; moreover, the homeodomains of several other transcription ...
L K, Schaefer, S, Wang, T S, Schaefer
openaire   +2 more sources

Functional analysis of the homeodomain protein SIX5 [PDF]

Nucleic Acids Research, 2000
SIX5 (previously known as myotonic dystrophy associated homeodomain protein - DMAHP ) is a member of the SIX [ sine oculis homeobox (Drosophila ) homologue ] gene family which encodes proteins containing a SIX domain adjacent to a homeo-domain. To investigate the DNA binding specificities of these two domains in SIX5, they were expressed as GST fusion ...
Harris, S E, Winchester, C L, Johnson, K J   +2 more
openaire   +3 more sources

ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity. [PDF]

PLoS ONE, 2012
Interactions with cofactors regulate transcriptional activity and also help HOX proteins to achieve the specificity required for transcriptional regulation of target genes. In this study, we describe a novel protein/protein interaction of HOXB7 with poly
Xinyan Wu, Stephan Ellmann, Ethel Rubin, Minchan Gil, Kideok Jin, Liangfeng Han, Hexin Chen, Erika M Kwon, Jianhui Guo, Hyo Chol Ha, Saraswati Sukumar   +10 more
doaj   +1 more source

Homeodomain proteins in action: similar DNA binding preferences, highly variable connectivity. [PDF]

, 2017
: Homeodomain proteins are evolutionary conserved proteinspresent in the entire eukaryote kingdom. They execute functions that areessential for life, both in developing and adult organisms.
Merabet, Samir, Bobola, Nicoletta
core   +1 more source

A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. [PDF]

PLoS ONE, 2009
The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to
Jeffrey T Irelan, Ana Gutierrez Del Arroyo, Abel Gutierrez, Gordon Peters, Kim C Quon, Loren Miraglia, Sumit K Chanda   +6 more
doaj   +1 more source

An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression

Nature Communications, 2022
Vascular addressins control lymphocyte homing, thus regulating immunity and inflammation, but how addressin expression is patterned remains unknown.
Thanh Theresa Dinh, Menglan Xiang, Anusha Rajaraman, Yongzhi Wang, Nicole Salazar, Yu Zhu, Walter Roper, Siyeon Rhee, Kevin Brulois, Ed O’Hara, Helena Kiefel, Truc M. Dinh, Yuhan Bi, Dalila Gonzalez, Evan P. Bao, Kristy Red-Horse, Peter Balogh, Fanni Gábris, Balázs Gaszner, Gergely Berta, Junliang Pan, Eugene C. Butcher   +21 more
doaj   +1 more source

Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox [PDF]

, 2019
The Drosophila homeodomain-interacting protein kinase (Hipk) is the fly representative of the well-conserved group of HIPKs in vertebrates. It was initially found through its characteristic interactions with homeodomain proteins.
Steinmetz, Eva Louise, Dewald, Denise Nicole, Luxem, Nadine, Walldorf, Uwe   +3 more
core   +1 more source