Functional Interaction of Jun and Homeodomain Proteins [PDF]
Journal of Biological Chemistry, 2001 We have used the yeast two-hybrid system to identify proteins that interact with the N-terminal region of c-Jun, which is known to be involved in regulatory interactions. One of the proteins identified is the homeodomain-containing protein Hex. The Hex homeodomain is sufficient for interaction; moreover, the homeodomains of several other transcription ...
L K, Schaefer, S, Wang, T S, Schaefer
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Functional analysis of the homeodomain protein SIX5 [PDF]
Nucleic Acids Research, 2000 SIX5 (previously known as myotonic dystrophy associated homeodomain protein - DMAHP ) is a member of the SIX [ sine oculis homeobox (Drosophila ) homologue ] gene family which encodes proteins containing a SIX domain adjacent to a homeo-domain. To investigate the DNA binding specificities of these two domains in SIX5, they were expressed as GST fusion ...
Harris, S E +2 more
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A Petunia homeodomain-leucine zipper protein, PhHD-Zip, plays an important role in flower senescence. [PDF]
, 2014 Flower senescence is initiated by developmental and environmental signals, and regulated by gene transcription. A homeodomain-leucine zipper transcription factor, PhHD-Zip, is up-regulated during petunia flower senescence. Virus-induced gene silencing of
Chang, Xiaoxiao +5 more
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Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]
, 2009 The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Greene, W.K. +4 more
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A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. [PDF]
PLoS ONE, 2009 The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to
Jeffrey T Irelan +6 more
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The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development [PDF]
, 2003 LIM homeobox family members regulate a variety of cell fate choices during animal development. In C. elegans, mutations in the LIM homeobox gene lin-11 have previously been shown to alter the cell division pattern of a subset of the 2° lineage vulval ...
Gupta, Bhagwati P. +2 more
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NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells
BMC Cancer, 2009 Background Homeodomain proteins control fundamental cellular processes in development and in cancer if deregulated. Three members of the NK-like subfamily of homeobox genes (NKLs), TLX1, TLX3 and NKX2-5, are implicated in T-cell acute lymphoblastic ...
Drexler Hans G +10 more
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ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity. [PDF]
PLoS ONE, 2012 Interactions with cofactors regulate transcriptional activity and also help HOX proteins to achieve the specificity required for transcriptional regulation of target genes. In this study, we describe a novel protein/protein interaction of HOXB7 with poly
Xinyan Wu +10 more
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Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. [PDF]
, 2017 BackgroundProper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to ...
Brayman, Melissa J +6 more
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An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression
Nature Communications, 2022 Vascular addressins control lymphocyte homing, thus regulating immunity and inflammation, but how addressin expression is patterned remains unknown.
Thanh Theresa Dinh +21 more
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