Unconventional Secretion, Gate to Homeoprotein Intercellular Transfer
Frontiers in Cell and Developmental Biology, 2022 Unconventional secretion allows for the secretion of fully mature and biologically active proteins mostly present in the cytoplasm or nucleus. Besides extra vesicle-driven secretion, non-extravesicular pathways also exist that specifically rely on the ...
Alain Joliot, Alain Prochiantz
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A Recessive Mutation Resulting in a Disabling Amino Acid Substitution (T194R) in the LHX3 Homeodomain Causes Combined Pituitary Hormone Deficiency [PDF]
, 2012 Background/Aims: Recessive mutations in the LHX3 homeodomain transcription factor gene are associated with developmental disorders affecting the pituitary and nervous system. We describe pediatric patients with combined pituitary hormone deficiency (CPHD)
Hiedl, Stefan +7 more
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Homeodomain proteins directly regulate ATM kinase activity [PDF]
, 2020 The ataxia-telangiectasia mutated (ATM) kinase is a master regulator involved in the detection and repair of DNA double-strand breaks (DSBs). The Mre11/Rad50/Nbs1 (MRN) complex recruits and activates ATM at DSBs, causing a signaling cascade to initiate ...
Johnson, Tanya Ellen
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Functional Interaction of Jun and Homeodomain Proteins [PDF]
Journal of Biological Chemistry, 2001 We have used the yeast two-hybrid system to identify proteins that interact with the N-terminal region of c-Jun, which is known to be involved in regulatory interactions. One of the proteins identified is the homeodomain-containing protein Hex. The Hex homeodomain is sufficient for interaction; moreover, the homeodomains of several other transcription ...
L K, Schaefer, S, Wang, T S, Schaefer
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Functional analysis of the homeodomain protein SIX5 [PDF]
Nucleic Acids Research, 2000 SIX5 (previously known as myotonic dystrophy associated homeodomain protein - DMAHP ) is a member of the SIX [ sine oculis homeobox (Drosophila ) homologue ] gene family which encodes proteins containing a SIX domain adjacent to a homeo-domain. To investigate the DNA binding specificities of these two domains in SIX5, they were expressed as GST fusion ...
Harris, S E +2 more
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Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development [PDF]
, 2002 The crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated.
Bossenz, Michael +6 more
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ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity. [PDF]
PLoS ONE, 2012 Interactions with cofactors regulate transcriptional activity and also help HOX proteins to achieve the specificity required for transcriptional regulation of target genes. In this study, we describe a novel protein/protein interaction of HOXB7 with poly
Xinyan Wu +10 more
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Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]
, 2009 The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Heidari, M. +10 more
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NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells
BMC Cancer, 2009 Background Homeodomain proteins control fundamental cellular processes in development and in cancer if deregulated. Three members of the NK-like subfamily of homeobox genes (NKLs), TLX1, TLX3 and NKX2-5, are implicated in T-cell acute lymphoblastic ...
Drexler Hans G +10 more
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A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. [PDF]
PLoS ONE, 2009 The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to
Jeffrey T Irelan +6 more
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