Results 51 to 60 of about 41,966 (223)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development [PDF]

, 2002
The crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated.
Bossenz, Michael, Peirano, Reto I, Becker, Thomas, Ostendorff, Heather P, Bach, Ingolf, Schlüter, Anne, Becker, Catherina G   +6 more
core   +1 more source

Analysis of homeobox gene action may reveal novel angiogenic pathways in normal placental vasculature and in clinical pregnancy disorders associated with abnormal placental angiogenesis.

Frontiers in Pharmacology, 2014
Homeobox genes are essential for both the development of the blood and lymphatic vascular systems, as well as for their maintenance in the adult. Homeobox genes comprise an important family of transcription factors, which are characterised by a well ...
Padma eMurthi, Padma eMurthi, Mohamed eAbumaree, Mohamed eAbumaree, Bill eKalionis, Bill eKalionis   +5 more
doaj   +1 more source

A conserved tissue-specific homeodomain-less isoform of MEIS1 is downregulated in colorectal cancer. [PDF]

PLoS ONE, 2011
Colorectal cancer is one of the most common cancers in developed nations and is the result of both environmental and genetic factors. Many of the genetic lesions observed in colorectal cancer alter expression of homeobox genes, which encode homeodomain ...
Richard C Crist, Jacquelyn J Roth, Scott A Waldman, Arthur M Buchberg   +3 more
doaj   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

LIM-homeodomain proteins Lhx3 and Lhx8 induce the cholinergic neurotransmitter identity in spinal motor neurons and forebrain cholinergic neurons through Isl1 and NLI hexamer complex transcriptional activity. [PDF]

, 2014
LIM-homeodomain proteins Lhx3 and Lhx8 induce the cholinergic neurotransmitter identity in spinal motor neurons and forebrain cholinergic neurons through Isl1 and NLI hexamer complex transcriptional activity.
Artur Kania (179904)
core   +1 more source

The iroquois homeodomain proteins are required to specify body wall identity in Drosophila [PDF]

, 2020
The Iroquois complex (Iro-C) homeodomain proteins allow cells at the proximal part of the Drosophila imaginal wing disc to form mesothoracic body wall (notum). Cells lacking these proteins form wing hinge structures instead (tegula and axillary sclerites)
Modolell, Juan, Díez del Corral, Ruth, Aroca, Pilar, Gómez-Skarmeta, José Luis, Cavodeassi, Florencia   +4 more
core   +1 more source

The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2

Nature Communications
The CUT and homeodomain are ubiquitous DNA binding elements often tandemly arranged in multiple transcription factor families. However, how the CUT and homeodomain work concertedly to bind DNA remains unknown.
Avradip Chatterjee, Brad Gallent, Madhusudhanarao Katiki, Chen Qian, Matthew R. Harter, Steve Silletti, Elizabeth A. Komives, Michael R. Freeman, Ramachandran Murali   +8 more
doaj   +1 more source

Cytosolic sequestration of Prep1 influences early stages of T cell development.

PLoS ONE, 2008
ObjectivePrep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus. We previously reported reduced Pbx2 expression and defective thymocyte maturation in Prep1 hypomorphic ...
Dmitry Penkov, Martina Palazzolo, Anna Mondino, Francesco Blasi   +3 more
doaj   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source