Results 51 to 60 of about 1,590,984 (213)
Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders [PDF]
, 2001 The homeobox gene Hesx1/HESX1 has been implicated in the establishment of anterior pattern in the central nervous system (CNS) in a number of vertebrate species.
Tyrell, R +17 more
core
The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1. [PDF]
PLoS ONE, 2013 Hox proteins are conserved homeodomain transcription factors known to be crucial regulators of animal development. As transcription factors, the functions and modes of action (co-factors, target genes) of Hox proteins have been very well studied in a ...
Isabelle Bergiers +4 more
doaj +1 more source
Advanced Science, EarlyView.SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao +10 more
wiley +1 more source
Frontiers in Pharmacology, 2014 Homeobox genes are essential for both the development of the blood and lymphatic vascular systems, as well as for their maintenance in the adult. Homeobox genes comprise an important family of transcription factors, which are characterised by a well ...
Padma eMurthi +5 more
doaj +1 more source
Advanced Science, EarlyView.This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou +4 more
wiley +1 more source
Amino acid sequence conservation in homeodomain proteins.
, 2022 Sequence logo plots of protein domains involve in the function of homeodomain proteins. Although the C-terminal domain was not related to a function, it was displayed due to its high conservation in protein sequences. Amino acids are colored according to
Vilde Bruhn Kinneberg (12328777) +7 more
core +1 more source
The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2
Nature CommunicationsThe CUT and homeodomain are ubiquitous DNA binding elements often tandemly arranged in multiple transcription factor families. However, how the CUT and homeodomain work concertedly to bind DNA remains unknown.
Avradip Chatterjee +8 more
doaj +1 more source
Cytosolic sequestration of Prep1 influences early stages of T cell development.
PLoS ONE, 2008 ObjectivePrep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus. We previously reported reduced Pbx2 expression and defective thymocyte maturation in Prep1 hypomorphic ...
Dmitry Penkov +3 more
doaj +1 more source
A conserved tissue-specific homeodomain-less isoform of MEIS1 is downregulated in colorectal cancer. [PDF]
PLoS ONE, 2011 Colorectal cancer is one of the most common cancers in developed nations and is the result of both environmental and genetic factors. Many of the genetic lesions observed in colorectal cancer alter expression of homeobox genes, which encode homeodomain ...
Richard C Crist +3 more
doaj +1 more source
Karyopherins in nuclear transport of homeodomain proteins during development. [PDF]
Biochim Biophys Acta, 2011 Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic ...
Ye W, Lin W, Tartakoff AM, Tao T.
europepmc +2 more sources