Results 71 to 80 of about 65,874 (228)
Intercellular Trafficking of Homeodomain Proteins
The Plant Pathology Journal, 2005 Homeotic proteins have pivotal roles during the development of both plant and animals. Many homeotic proteins exert control over cell fate in cells where their genes are not expressed, i.e., in a non-cell autonomous manner. Cell-to-cell communication, which delivers critical information for position-dependent specification of cell fate, is an essential
Seon-Won Kim +10 more
openaire +2 more sources
eLife, 2015 We take a functional genomics approach to congenital heart disease mechanism. We used DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated NKX2-5 mutations to model loss-of-function in gene regulatory networks. NKX2-
Romaric Bouveret +17 more
doaj +1 more source
Pax3 stimulates p53 ubiquitination and degradation independent of transcription. [PDF]
PLoS ONE, 2011 Pax3 is a developmental transcription factor that is required for neural tube and neural crest development. We previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardiac neural crest defects in Pax3-mutant mouse
Xiao Dan Wang +2 more
doaj +1 more source
The transcription factors BEL1 and SPL are required for cytokinin and auxin signaling during ovule development in Arabidopsis [PDF]
, 2012 Hormones, such as auxin and cytokinin, are involved in the complex molecular network that regulates the coordinated development of plant organs. Genes controlling ovule patterning have been identified and studied in detail; however, the roles of auxin ...
Bencivenga, Stefano +3 more
core +3 more sources
Zebrafish inversin mutants develop scoliosis in the absence of laterality defects
Developmental Dynamics, EarlyView.Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick +3 more
wiley +1 more source
Spatial mechanisms of gene regulation in metazoan embryos [PDF]
, 1991 The basic characteristics of embryonic process throughout Metazoa are considered with focus on those aspects that provide insight into how cell specification occurs in the initial stages of development.
Davidson, Eric H.
core
Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins [PDF]
, 1995 Cells translate extracellular signals into specific programs of gene expression that reflect their developmental history or identity. We present evidence that one way this interpretation may be performed is by cooperative interactions between serum ...
Grueneberg, D. A. +3 more
core +1 more source
Developmental Dynamics, EarlyView.Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane +4 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2016 Upon fertilization Chlamydomonas reinhardtii zygotes undergo a program of differentiation into a diploid zygospore that is accompanied by transcription of hundreds of zygote-specific genes.
Takashi Hamaji +3 more
doaj +1 more source
The Homeodomain Iroquois Proteins Control Cell Cycle Progression and Regulate the Size of Developmental Fields. [PDF]
PLoS Genetics, 2015 During development, proper differentiation and final organ size rely on the control of territorial specification and cell proliferation. Although many regulators of these processes have been identified, how both are coordinated remains largely unknown ...
Natalia Barrios +3 more
doaj +1 more source