Results 91 to 100 of about 41,966 (223)

Purification and characterization of a DNA-binding recombinant PREP1:PBX1 complex. [PDF]

PLoS ONE, 2015
Human PREP1 and PBX1 are homeodomain transcriptional factors, whose biochemical and structural characterization has not yet been fully described. Expression of full-length recombinant PREP1 (47.6 kDa) and PBX1 (46.6 kDa) in E.
Lisa Mathiasen, Chiara Bruckmann, Sebastiano Pasqualato, Francesco Blasi   +3 more
doaj   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

The HOXC6 homeodomain-containing proteins.

The international journal of biochemistry & cell biology, 1998
The HOXC6 homeodomain-containing proteins act as transcription factors in the genetic control of multiple genes involved in development and cell differentiation. Two HOXC6 polypeptides are encoded by a single homeobox ('HOX') gene described as 'master gene' for the crucial role it plays in the patterning and axial morphogenesis of multiple species ...
Chariot, Alain, Gielen, jacques
openaire   +2 more sources

Abstract 1157: Ubiquitin-proteolytic control of HOX homeodomain proteins in normal and malignant hematopoiesis [PDF]

, 2010
The HOX homeodomain proteins are key regulators of hematopoiesis. HOX genes are expressed in primitive hematopoietic cells, and their prompt downregulation is associated with hematopoietic differentiation and maturation.
Jennifer Lee, Jianxuan Zhang, Pengbo Zhou, Jae-Hung Shieh, Malcolm A. S. Moore, Liren Liu   +5 more
core   +1 more source

The ALX4 dimer structure provides insight into how disease alleles impact function

Nature Communications
How homeodomain proteins gain sufficient DNA binding specificity to regulate diverse processes is a long-standing question. Here, we determine how the ALX4 Paired-like protein achieves DNA binding specificity for a TAAT–NNN–ATTA dimer site. We first show
Brittany Cain, Zhenyu Yuan, Evelyn Thoman, Rhett A. Kovall, Brian Gebelein   +4 more
doaj   +1 more source

Role of the tomato MARS1/ROUGH gene encoding a LYSINE‐SPECIFIC HISTONE DEMETHYLASE 1 in adventitious root and fruit skin formation

Journal of Integrative Plant Biology, EarlyView.
The tomato mars1/rough mutant displays enhanced root regeneration and rough fruits due to ectopic cell proliferation. The causal gene encodes a lysine‐specific histone demethylase that normally maintains gene silencing. Its loss alters histone methylation, upregulating several genes, including those B‐type cyclins involved in tissue‐specific cellular ...
Eduardo Larriba, Cécile Bres, Aurora Alaguero‐Cordovilla, Riyazuddin Riyazuddin, Qingyi Wang, Johann Petit, Jean‐Philippe Mauxion, Lara Caballero, David Latrasse, Bénédicte Bakan, Rim Brik‐Chaouche, David Esteve‐Bruna, Moussa Benhamed, Christophe Rothan, José Manuel Pérez‐Pérez   +14 more
wiley   +1 more source

Isolation and characterization of the chicken homeodomain protein AKR

Nucleic Acids Research, 1995
Expression of the avian apoVLDLII gene is liver specific and completely dependent on estrogen. Previous analyses of protein binding sites in the apoVLDLII promoter revealed interactions between liver-enriched and ubiquitous factors at a location, site F', between nucleotides -229 and -260 relative to the major transcriptional start site.
A K, Ryan, M L, Tejada, D L, May, M, Dubaova, R G, Deeley   +4 more
openaire   +3 more sources

Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins [PDF]

, 2004
Little is known about the molecular mechanisms that integrate anteroposterior (AP) and dorsoventral (DV) positional information in neural progenitors that specify distinct neuronal types within the vertebrate neural tube. We have previously shown that in
G. Caronia, I. Variet, Johan Ericson, Filippo M. Rijli, MJ Geisen, Christo Goridis, Giuliana Caronia, Isabelle Varlet, FM Rijli, ZAPPAVIGNA, Vincenzo, J. Ericson, Marc J. Geisen, OA Samad, Omar Abdel Samad, C. Goridis, Vincenzo Zappavigna   +15 more
core   +1 more source

Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation

Journal of Integrative Plant Biology, EarlyView.
This review focuses on mitogen‐activated protein kinase (MAPK) activation and summarizes how plants regulate and integrate MAPK signaling in modulating plant immune responses. It also examines the effectors pathogens have evolved to manipulate MAPK activation and thereby inhibit plant immunity.
Guitao Zhong, Zhanchun Wang, Dingzhong Tang, Wei Wang   +3 more
wiley   +1 more source

Interactions between Homeodomain proteins and Shh-Gli pathway in brain tumors and the stem cells [PDF]

, 2009
This work describes the function of two homeodomain proteins, HOP and NANOG, a family of protein previously known for their involvement in organogenesis and embryo patterning, in the context of gliomas, a tumor with a very poor prognosis. In addition, we
Zbinden, Marie
core   +1 more source