Results 81 to 90 of about 1,590,984 (213)

The proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation. [PDF]

PLoS ONE, 2012
Many transcription factors control gene expression by binding to specific DNA sequences at or near the genes that they regulate. However, some transcription factors play more global roles in the control of gene expression by altering the architecture of ...
Anshuman Shukla, Nicholas M Burton, Padma-Sheela Jayaraman, Kevin Gaston   +3 more
doaj   +1 more source

Hox Gene Variation Drives Morphological Specialization of Humpback Grouper Cromileptes altivelis

Integrative Zoology, EarlyView.
Cromileptes altivelis exhibits a distinctive “sunken head and humpback” morphology, formed through cranial remodeling. Genetic analyses identified unique amino acid variants in Hoxa7a and Hoxa10b, with functional tests confirming their role in enhancing osteoblast activity and driving cranial remodeling.
Xiaoying Cao, Zhaowei Zhong, Lisheng Wu, Quanyin Liu, Shaoxiong Ding   +4 more
wiley   +1 more source

Genome wide binding (ChIP-Seq) of murine Bapx1 and Sox9 proteins in vivo and in vitro

Genomics Data, 2016
This work pertains to GEO submission GSE36672, in vivo and in vitro genome wide binding (ChIP-Seq) of Bapx1/Nkx3.2 and Sox9 proteins. We have previously shown that data from a genome wide binding assay combined with transcriptional profiling is an ...
Sumantra Chatterjee, Petra Kraus, V. Sivakamasundari, Sook Peng Yap, Vibhor Kumar, Shyam Prabhakar, Thomas Lufkin   +6 more
doaj   +1 more source

Integrated Multi‐Omics Analysis Reveals the Genetic Basis of Phenotypic Variation in Tibetan Sheep

Integrative Zoology, EarlyView.
SNaPshot‐validated GWAS results demonstrated significant correlations between candidate single nucleotide polymorphisms (SNPs) and body size traits in Tibetan sheep. Concurrently, hematoxylin and eosin staining, alongside muscle fiber analysis, confirmed pronounced morphological differences in muscle tissue between sheep of varying conformation.
Dehui Liu, Xue Li, Fei Tian, Xuexia Li, Wenxia Li, Buying Han, Ming Jiang, Yanlan Liu, Xiliu Hu, Xue Xiang, Wulong Ma, Guangcai Bao, Rong Li, Guoxiang Bao, Sijia Liu, Kai Zhao, Dehong Tian   +16 more
wiley   +1 more source

Functional analysis of the HOX11 target genes ALDH1A1 and FHL1 [PDF]

, 2004
HOX11 is a developmental regulator that plays a crucial role in the normal development of the spleen and is also aberrantly activated by the t(10;14)(q24;q11) and variant t(7;10)(q35;q24) translocations in a subset of T-cell acute lymphoblastic ...
Rice, Kim
core  

Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor

, 1992
Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity.
Gilman, M. Z., Grueneberg, D. A., Alexandre, C., Natesan, S.   +3 more
core   +1 more source

The ALX4 dimer structure provides insight into how disease alleles impact function

Nature Communications
How homeodomain proteins gain sufficient DNA binding specificity to regulate diverse processes is a long-standing question. Here, we determine how the ALX4 Paired-like protein achieves DNA binding specificity for a TAAT–NNN–ATTA dimer site. We first show
Brittany Cain, Zhenyu Yuan, Evelyn Thoman, Rhett A. Kovall, Brian Gebelein   +4 more
doaj   +1 more source

Ring the BELL and tie the KNOX: Roles for TALEs in gynoecium development

Frontiers in Plant Science, 2014
Carpels are leaf-like structures that bear ovules, and thus play a crucial role in the plant life cycle. In angiosperms, carpels are the last organs produced by the floral meristem and they differentiate a specialized meristematic tissue from which ...
Nicolas eArnaud, Véronique ePautot
doaj   +1 more source

microRNA‐mediated control of cell fate specification and patterning in Marchantia polymorpha

New Phytologist, EarlyView.
The gemma developmental program in Marchantia polymorpha is coordinated by MpMIR166‐mediated repression of MpC3HDZ and auxin homeostasis. Summary MicroRNAs (miRNAs) are small non‐coding RNA molecules essential for growth and development in eukaryotes. In plants, the master gene DICER‐LIKE 1 (DCL1) catalyzes the biogenesis of miRNAs by processing double‐
Adolfo Aguilar‐Cruz, Eduardo Flores‐Sandoval, Ye Xu, Yu Yu, Ximena Gutiérrez‐Ramos, Cristian Y. González‐Rangel, Omar Oltehua‐López, Ana E. Dorantes‐Acosta, Joshua T. Trujillo, Hirotaka Kato, Kimitsune Ishizaki, Rebecca A. Mosher, Liam Dolan, Xuemei Chen, Daniel Grimanelli, Jim Haseloff, John L. Bowman, Mario A. Arteaga‐Vazquez   +17 more
wiley   +1 more source

A Gain‐of‐Function Mutation in DELLA Selectively Alters Protein Interactions to Regulate Wheat Tiller Angle and Plant Height

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant architecture, especially plant height and tiller angle, plays a pivotal role in determining wheat yield. In this study, we characterize a wheat mutant termed prostrate and semidwarf 1 (prose1), exhibiting both a prostrate growth habit and semidwarfism.
Chaoqun Dong, Dejie Du, Yingying Li, Siyao Jia, Zhe Zhang, Yiqing Wang, Shuai Zheng, Xincheng Wang, Mingming Xin, Yingyin Yao, Lingling Chai, Zhongfu Ni, Qixin Sun, Jie Liu   +13 more
wiley   +1 more source