Results 31 to 40 of about 10,673,510 (116)

Expression of activity-dependent neuroprotective protein in the brain of adult rats [PDF]

, 2008
Activity-dependent neuroprotective protein (ADNP) is a VIP-regulated gene, which is essential for brain development. A synthetic peptide (NAP) derived from the ADNP sequence is highly neuroprotective, therefore it has been hypothesised that ADNP has ...
Quinn, J.P., Kipar, A., Bubb, V.J., Gennet, N., Herden, C.   +4 more
core  

PACAP and NAP : Effect of Two Functionally Related Peptides in Diabetic Retinopathy [PDF]

, 2021
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a peptide involved in physio-pathological processes of the eye. It exerts multiple effects directly through activation of its related receptors and indirectly through increases in the ...
Musumeci, Giuseppe, Reglődi, Dóra, D'Agata, Velia, D'Amico, Agata Grazia, Maugeri, Grazia   +4 more
core   +1 more source

ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4

, 2020
ADNP (Activity Dependent Neuroprotective Protein) is proposed as a neuroprotective protein whose aberrant expression has been frequently linked to rare neural developmental disorders and cancers, including the recently described neurodevelopmental ...
Yu, WenJun, Sun, XiaoYun, Li, Li, Sun, YuHua   +3 more
core   +1 more source

Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors [PDF]

, 2011
The extent to which brain slices reflect the energetic status of the in vivo brain has been a subject of debate. We addressed this issue to investigate the recovery of energetic parameters and adenine nucleotides in rat hippocampal slices and the ...
D. Grahame Hardie, Hardie, D. G. (D. Grahame), Naomi Pentland, Simon Hawley, Frenguelli, Bruno, Doney, Alexander S., Pentland, Naomi, Frenguelli, Bruno G., Stephanie zur Nedden, Hawley, Simon, Alexander S. Doney, Bruno G. Frenguelli, Hardie, D. Grahame, Doney, Alexander S.; id_orcid, Zur Nedden, Stephanie   +14 more
core   +1 more source

Protective inherited mutations in activity-dependent neuroprotective protein (ADNP): the good, the bad, and the ugly

Genomic Psychiatry
Activity-dependent neuroprotective protein (ADNP), essential for brain formation/function, reveals multiple cytoplasmic and chromatin interacting sites. Computational modeling, alongside the Vineland Adaptive Behavior Scales, a leading instrument supporting the diagnosis of intellectual/developmental disabilities, now revealed a protective frame shift ...
Illana Gozes, Shula Shazman, Eliezer Giladi, Joseph Levine   +3 more
openaire   +1 more source

ADNP: In search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration [PDF]

, 2015
Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer’s disease (AD) and in schizophrenia and mutated in autism. In mice, ADNP is essential for brain formation and ADNP haploinsufficiency is associated with cognitive and social ...
Yanina Ivashko-Pachima, Illana eGozes, Illana Gozes, Yanina eIvashko-Pachima   +3 more
core   +1 more source

Age and Sex-Dependent ADNP Regulation of Muscle Gene Expression Is Correlated with Motor Behavior: Possible Feedback Mechanism with PACAP

, 2020
The activity-dependent neuroprotective protein (ADNP), a double-edged sword, sex-dependently regulates multiple genes and was previously associated with the control of early muscle development and aging.
Illana Gozes, Eliezer Giladi, Adva Hadar, Oxana Kapitansky, Iman Jaljuli, Shlomo Sragovich   +5 more
core   +1 more source

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]

, 2007
Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
Kelly, April P., Cantrell, Doreen A., Wood, C. David, Matthews, Sharon A.   +3 more
core   +1 more source

Distinct Impairments Characterizing Different ADNP Mutants Reveal Aberrant Cytoplasmic-Nuclear Crosstalk

, 2022
(1) Background: Activity-dependent neuroprotective protein (ADNP) is essential for neuronal structure and function. Multiple de novo pathological mutations in ADNP cause the autistic ADNP syndrome, and they have been further suggested to affect Alzheimer&
Gidon Karmon, Yanina Ivashko-Pachima, Ivashko-Pachima, Yanina, Maram Ganaiem, Illana Gozes, Gozes, Illana, Ganaiem, Maram, Karmon, Gidon   +7 more
core   +1 more source

Single Cell ADNP Predictive of Human Muscle Disorders: Mouse Knockdown Results in Muscle Wasting

, 2020
Activity-dependent neuroprotective protein (ADNP) mutations are linked with cognitive dysfunctions characterizing the autistic-like ADNP syndrome patients, who also suffer from delayed motor maturation.
Gidon Karmon, Lior Bikovski, Robert Palovics, Tal Iram, Meishar Shahoha, Illana Gozes, Eliezer Giladi, Adva Hadar, Oxana Kapitansky, Iman Jaljuli, Shlomo Sragovich   +10 more
core   +1 more source