Results 21 to 30 of about 10,673,510 (116)

The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins [PDF]

Molecular Psychiatry, 2014
The NAP motif of activity-dependent neuroprotective protein (ADNP) enhanced memory scores in patients suffering from mild cognitive impairment and protected activities of daily living in schizophrenia patients, while fortifying microtubule (MT)-dependent axonal transport, in mice and flies. The question is how does NAP fortify MTs?
S, Oz, O, Kapitansky, Y, Ivashco-Pachima, A, Malishkevich, E, Giladi, N, Skalka, R, Rosin-Arbesfeld, L, Mittelman, O, Segev, J A, Hirsch, I, Gozes   +10 more
openaire   +2 more sources

HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats. [PDF]

, 2011
H3 lysine 9 trimethylation (H3K9me3) is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin.
Singh, P., Franz Henriette, Franz, H., Szabolcs Soeroes, Prim B. Singh, Fischle, W., Soeroes Szabolcs, Wolfgang Fischle, Singh Prim B., Mosch, K., Kerstin Mosch, Sörös, S., Fischle Wolfgang, Henriette Franz, Mosch Kerstin, Prim B Singh   +15 more
core   +2 more sources

Objective frequency analysis of transient visual evoked potentials in activity dependent neuroprotective protein (adnp) syndrome

, 2023
Doctoral dissertation, PhD / YU onlyTime-and frequency-domain measures of transient visual evoked potentials (tVEPs) were examined to advance understanding of neural differences in children with activity dependent neuroprotective protein (ADNP) syndrome.
Benrey Grinberg, Nurit Esther
core  

In Search of the Hidden Protein: Optimization of Detection Strategies for autism-associated Activity-Dependent Neuroprotective Protein (ADNP) mutants.

, 2022
AbstractHeterozygousde novomutations in theActivity-Dependent Neuroprotective Homeobox(ADNP) protein were found to be the common cause underlying the Helsmoortel-Van der Aa syndrome (HVDAS). With most of the patient mutations situated in the last exon, we previously demonstrated the predicted escape from nonsense-mediated decay by detecting ...
Claudio Peter D'Incal, Elisa Cappuyns, Kaoutar Choukri, Kristy Szrama, Kevin De Man, Nathalie Van der Aa, Anke van Dijck, R. Frank Kooy, Wim Vanden Berghe   +8 more
openaire   +1 more source

ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling

, 2020
ADNP (Activity Dependent Neuroprotective Protein) is a neuroprotective protein whose aberrant expression has been frequently linked to neural developmental disorders, including the Helsmoortel-Van der Aa syndrome (also called the ADNP syndrome). However,
Sun, Xiaoyun, Zhou, Yan, Peng, Xixia, Xixia Peng, Yuqin Cao, Cao, Yuqin, Sun, Yuhua, Yan Zhou, Xiaoyun Sun, Yuhua Sun   +9 more
core   +1 more source

Cloning and characterization of the human activity-dependent neuroprotective protein

, 2001
We have recently cloned the mouse activity-dependent neuroprotective protein (ADNP). Here, we disclose the cloning of human ADNP (hADNP) from a fetal brain cDNA library.
Mulley, J., Gozes, I., Brenneman, D., Seroussi, E., Pinhasov, A., Steingart, R., Giladi, E., Wollman, Y., Bassan, M., Zamostiano, R., Gelber, E., Eyre, H.   +11 more
core   +1 more source

Protective activity of aromatic amines and imines against oxidative nerve cell death [PDF]

, 2001
Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Skutella, T., Behl, Christian, Beyer, Klaus, Moosmann, Bernd, Behl, C., Moosmann, B., Beyer, K., Skutella, Thomas   +7 more
core   +1 more source

Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure

Neurobiology of Disease, 2008
Activity-dependent neuroprotective protein (ADNP) is widely distributed in the cytoplasm of neurons and astrocytes of the hippocampus. Kainic acid (KA)-induced seizures increases neuronal nitric oxide synthase (nNOS) in neurons and inducible NOS (iNOS) in glia cells which coincides with a reduction in ADNP in the hippocampus.
Anna S. Cosgrave, Jennifer S. McKay, Vivien Bubb, Richard Morris, John P. Quinn, Thimmasettappa Thippeswamy   +5 more
openaire   +3 more sources

Dissecting the Role of Adnp in Neurogenesis Using the Mouse Retina as a Model System

, 2023
The ADNP (Activity dependent neuroprotective protein) gene encodes a transcription factor that is essential for embryonic development and brain formation.
Medisetti, Suma
core   +1 more source

A novel davunetide (NAPVSIPQ Q to NAPVSIPQ E ) point mutation in activity‐dependent neuroprotective protein (ADNP) causes a mild developmental syndrome

European Journal of Neuroscience, 2023
Abstract NAP (NAPVSIPQ, drug candidate name, davunetide) is the neuroprotective fragment of activity‐dependent neuroprotective protein (ADNP). Recent studies identified NAPVSIP as a Src homology 3 (SH3) domain‐ligand association site, responsible for controlling signalling pathways regulating the cytoskeleton ...
Illana Gozes, Shula Shazman
openaire   +2 more sources