Results 101 to 110 of about 206,292 (219)

Drug–drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450

British Journal of Clinical Pharmacology, EarlyView.
Aims To assess the effect of a potent cytochrome P450 (CYP) 3A inhibitor and CYP inducer on the pharmacokinetics of ritlecitinib, a JAK3/TEC family kinase inhibitor, and assess the effect of ritlecitinib on the pharmacokinetics of CYP substrates (midazolam, efavirenz, tolbutamide, caffeine and oral contraceptives [ethinyl oestradiol and levonorgestrel])
Vivek S. Purohit, Yeamin Huh, Martin E. Dowty, Anna Plotka, Alexandre Lejeune, Hindu Kalluru, Brian Hee   +6 more
wiley   +1 more source

Using radio programming to reach young adolescents with gender and sexual health information in a low-income urban setting in Kenya. [PDF]

Reprod Health
Maina BW, Nyakangi V, Mbuthia M, Kabiru CW.   +3 more
europepmc   +1 more source

Alterations of appetite‐regulating hormones in risperidone treated children and adolescents—a post hoc analysis of the SPACe study

British Journal of Clinical Pharmacology, EarlyView.
Weight gain and metabolic disruptions are common in children and adolescents treated with antipsychotics, but the underlying mechanisms are unclear, complicating prevention and treatment. This study examines the impact of risperidone on appetite‐regulating hormones (insulin, leptin and bioleptin) and their relationship to body weight changes over time.
Jiayi Liang, Brenda C. M. de Winter, Rebecca A. Hermans, Sanne M. Kloosterboer, Susanne Kuckuck, Izgi Bayraktar, Liesbeth F. C. van Rossum, Manon H. J. Hillegers, Sander A. A. van den Berg, Birgit C. P. Koch, Bram Dierckx   +10 more
wiley   +1 more source

Peer Relationships Are a Direct Cause of the Adolescent Mental Health Crisis: Interpretable Machine Learning Analysis of 2 Large Cohort Studies.

JMIR Public Health Surveill
Stuke H, Schlack R, Erhart M, Kaman A, Ravens-Sieberer U, Irrgang C.   +5 more
europepmc   +1 more source

Mid-life outcomes of young people's antisocial behavior: the role of developmental heterogeneity across childhood and adolescence. [PDF]

Psychol Med
Popli G, Maughan B, Rowe R.
europepmc   +1 more source

Pharmacokinetics and pharmacodynamics of empagliflozin in paediatric patients aged 10–17 years with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Aims To characterize the pharmacokinetics (PK) and PK/pharmacodynamics (PD) regarding glycosylated haemoglobin (HbA1c) lowering using the paediatric data from DINAMO and to assess differences compared with adults. Methods Population PK and PK/PD models previously developed for empagliflozin in adults and adolescents were re‐estimated in a Bayesian ...
Juliane Rascher, Shen Cheng, Curtis Johnston, Sebastian Härtter, Wojtyniak Jan‐Georg, Jan Marquard, Igor Tartakovsky, Lori M. B. Laffel   +7 more
wiley   +1 more source

Depression, Anxiety, and Suicide Among Adolescents: Sex Differences and Future Perspectives. [PDF]

J Clin Med
Toro GVR, Arias P, de la Torre-Luque A, Singer JB, Lagunas N.   +4 more
europepmc   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Räisänen Laura, Balouch Fariha, Reilly Claire, Burgess Christopher, Peter Lewindon   +4 more
wiley   +1 more source

Influence of aging on facial attractiveness perception in individuals with normal occlusion.

Angle Orthod
Natsumeda G, Silva I, Miranda F, Massaro C, Garib D.   +4 more
europepmc   +1 more source

Social Contexts Requiring Adjudication Self- and Peer-Interest Differentially Alter Risk Preferences Across Adolescence. [PDF]

Open Mind (Camb)
Chen YY, Rosenbaum GM, Fan H, Flournoy JC, Li T, Cegarra L, Youssoufian DA, Grad-Freilich MJ, Kordyban LE, Mair P, Somerville LH.   +10 more
europepmc   +1 more source