Results 101 to 110 of about 1,181,122 (400)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants

Scientific Reports, 2019
Altogether, 20–30% of women receive intrapartum antibiotic prophylaxis (IAP) to prevent sepsis in infants and 2–5% of newborn infants receive antibiotics due to suspected sepsis.
Terhi Tapiainen, Pirjo Koivusaari, Lauren Brinkac, Hernan A. Lorenzi, Jarmo Salo, Marjo Renko, Hannele Pruikkonen, Tytti Pokka, Weizhong Li, Karen Nelson, Anna Maria Pirttilä, Mysore V. Tejesvi   +11 more
doaj   +1 more source

Prevalence and Clinical Significance of Symptoms at Ultra High Risk for Psychosis in Children and Adolescents with Obsessive–Compulsive Disorder: Is There an Association with Global, Role, and Social Functioning?

Brain Sciences, 2018
In literature nothing is known about the clinical significance of Ultra High Risk (UHR) symptoms in children and adolescents with diagnosis of obsessive–compulsive disorder (OCD).
Roberto Averna, Maria Pontillo, Francesco Demaria, Marco Armando, Ornella Santonastaso, Maria Laura Pucciarini, Maria Cristina Tata, Francesco Mancini, Stefano Vicari   +8 more
doaj   +1 more source

Peer victimization in childhood and internalizing problems in adolescence : a prospective longitudinal study [PDF]

, 2012
Traumatic childhood experiences have been found to predict later internalizing problems. This prospective longitudinal study investigated whether repeated and intentional harm doing by peers (peer victimization) in childhood predicts internalizing ...
Lereya, Suzet Tanya, Wolke, Dieter, Zwierzynska, Karolina   +2 more
core   +1 more source

Cyberbullying and Adolescents

Current Pediatrics Reports, 2020
Cyberbullying is an aggressive behavior involving a type of electronic communication intending to harm a victim that can have profound effects on adolescents. This review examines the epidemiology, issues from cyberbullying, presentation to care of its victims and proposed interventions to this behavior.There are a variety of physical and psychological
Vidhya Lakshmi, Kumar, Mark A, Goldstein
openaire   +3 more sources

Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task‐related Neuronal Activity

Advanced Science, EarlyView.
Genetic and chemical tracking of oligodendrogenesis, combining fiber photometric neuronal activity recording, reveals that distinct oligodendrocyte plasticities are adopted during different phases of motor learning to fine‐tune task‐related neuronal activity, with a preferential involvement of oligodendrogenesis suppression and node lengthening (type 2
Shuming Wang, Nuo Xu, Wenwen Wang, Yongxiang He, Yuqian Yang, Liuning Zhang, Yanping Zou, Yuehua He, Huiliang Li, Liang Gao, Lin Xiao   +10 more
wiley   +1 more source

Does Identity Precede Intimacy? Testing Erikson's Theory on Romantic Development in Emerging Adults of the 21st Century [PDF]

, 2010
Erikson stated that healthy identity development during adolescence is a precursor of intimacy in romantic relationships during emerging adulthood.
Beyers, Wim, Seiffge-Krenke, Inge
core   +2 more sources

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, EarlyView.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

Understanding suicidality in adolescents and young adults at clinical high risk for psychosis: a narrative review on risk factors and clinical insights

Frontiers in Psychiatry
The prodromal stage of psychosis, referred to as the Clinical High Risk (CHR) phase, represents a critical period of heightened vulnerability to suicidality.
Maria Pontillo, Cristina Di Vincenzo, Michelangelo Di Luzio, Francesco Demaria, Barbara D’Aiello, Ilaria Bertoncini, Massimo Apicella, Milena Labonia, Gino Maglio, Roberto Averna, Stefano Vicari, Stefano Vicari   +11 more
doaj   +1 more source

Self-efficacy, affectivity and smoking behavior in adolescence [PDF]

, 2011
Background: Research on health-related behaviors confirms the contribution of self-efficacy and affective factors to the initiation and continuation of smoking behavior. The aim was to assess the degree to which affectivity contributes to the association
Madarasova-Geckova, A., Reijneveld, S.A., van Dijk, J.P., Veselska, Z.   +3 more
core   +3 more sources