Results 81 to 90 of about 443,616 (316)

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Electrocardiographic markers of hypertrophy in children: revisiting R/S overlap and the Katz-Wachtel phenomenon

Frontiers in Pediatrics
BackgroundMany children show R/S overlap in ECG chest leads. The Katz-Wachtel phenomenon, described in the 1960s, characterizes high R and S waves ≥50 mm as an ECG feature of biventricular cardiac hypertrophy.
Nikola Owsianka, Lukas Schober, Hannes Sallmon, Daniel Scherr, n Köstenberger, Martin Manninger, Nathalie Öffl, Stefan Kurath-Koller   +7 more
doaj   +1 more source

Prevalence and Clinical Significance of Symptoms at Ultra High Risk for Psychosis in Children and Adolescents with Obsessive–Compulsive Disorder: Is There an Association with Global, Role, and Social Functioning?

Brain Sciences, 2018
In literature nothing is known about the clinical significance of Ultra High Risk (UHR) symptoms in children and adolescents with diagnosis of obsessive–compulsive disorder (OCD).
Roberto Averna, Maria Pontillo, Francesco Demaria, Marco Armando, Ornella Santonastaso, Maria Laura Pucciarini, Maria Cristina Tata, Francesco Mancini, Stefano Vicari   +8 more
doaj   +1 more source

Adolescent lives matter

Current Opinion in HIV and AIDS, 2018
Purpose of review Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be curtailed.
Pettifor, Audrey, Stoner, Marie, Pike, Carey, Bekker, Linda-Gail   +3 more
openaire   +3 more sources

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Identifying the role of emotion regulation strategies in predicting school adjustment in late childhood and adolescence

, 2013
Emotion regulation (ER) strategies, as conceptualised within the influential process model of ER (Gross, 1998), are found to be important predictors of psychological outcomes in adults.
Murphy, Rebecca Jane
core  

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, Accepted Article.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the CARRA, SPARTAN, and PRCSG Advisory Council   +9 more
wiley   +1 more source

Identifying Latent Profiles of Healthy Adults’ Biopsychosocial Pain Concepts

Pain Research and Management
Discussion: Results provide preliminary evidence for distinct profiles of biopsychosocial pain concepts among healthy adults. Further research should replicate these findings in clinical samples to better understand biopsychosocial pain concepts and ...
Catherina Lenhof, Laura Dukek, Linda Wickering, Lena Hitschler, Michael Schneider, Tanja Hechler   +5 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source