Results 61 to 70 of about 443,616 (316)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Insights on Adolescence From a Life Course Perspective

, 2011
In this essay, we argue that viewing adolescence within the full life course will improve our understanding of both adolescence itself and the life course more generally.
Johnson, Monica Kirkpatrick, Elder, Jr, Glen H, Monica Kirkpatrick Johnson, Robert Crosnoe, Crosnoe, Robert, Glen H. Elder   +5 more
core   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

Developmental differences in the structure of executive function in middle childhood and adolescence

, 2013
Although it has been argued that the structure of executive function (EF) may change developmentally, there is little empirical research to examine this view in middle childhood and adolescence.
Tengfei Wang, Yan Han (173242), Ren, Xuezhu, Chunhua Li (18618), Li, Chunhua, Fen Xu (326364), Sabbagh, Mark A., Yan Han, Chunhua Li, Tengfei Wang (477599), Xuezhu Ren (477600), Xuezhu Ren, Xu, Fen, Fen Xu, Mark A. Sabbagh (477598), Wang, Tengfei, Mark A Sabbagh, Han, Yan   +17 more
core   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Using feminist methodologies to explore female genital mutilation/cutting and child marriage in low- and middle-income contexts

Frontiers in Research Metrics and Analytics
This paper discusses how harmful practices such as child marriage and female genital mutilation/cutting (FGM/C) can be effectively explored through feminist methodologies that center the lived experiences of girls and young women affected by these issues.
Nicola Jones, Kate Pincock, Kate Pincock, Sarah Alheiwidi   +3 more
doaj   +1 more source

The development of identity in adolescence.

, 1991
PhDIn recent years, the development of identity in adolescence has become a popular issue in developmental psychology. In the present study seven hypotheses were formulated on this subject and tested.
Klein, Michele, Klein, M
core  

Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐Onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source

Development of the selection and manipulation of self-generated thoughts in adolescence

, 2010
The ability to select and manipulate self-generated (stimulus-independent, SI), as opposed to stimulus-oriented (SO), information, in a controlled and flexible way has previously only been studied in adults. This ability is thought to rely in part on the
Gilbert, S.J., Bano Hassan, Hassan, B., Blakemore, S.J., Dumontheil, Iroise, Iroise Dumontheil, Sarah-Jayne Blakemore, Sam J. Gilbert   +7 more
core   +1 more source

Insight of autonomic dysfunction in CLN3 disease: a study on episodes resembling paroxysmal sympathetic hyperactivity (PSH)

Orphanet Journal of Rare Diseases
Background Recurrent non-epileptic episodes resembling paroxysmal sympathetic hyperactivity (PSH) have been observed in adolescents with Juvenile Ceroid Lipofuscinosis (CLN3-disease) and a possible association to an autonomic dysfunction has been ...
C. Baekmann, M. M. Handrup, H. Molgaard, C. Ejerskov, H. K. Jensen, J. R. Ostergaard   +5 more
doaj   +1 more source