Results 121 to 130 of about 94,528 (347)

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2

Nature Communications
CD4+Foxp3+ regulatory T cells are essential for maintaining immune tolerance and preventing excessive inflammation, making them promising candidates for treating autoimmunity and GvHD.
Hao Cheng, Fang Nan, Ning Ji, Xiao Ma, Jianan Zhang, Hantian Liang, Wei Zhang, Hiroko Nakatsukasa, Huiyuan Zhang, Wenwen Jin, Hong Jiang, Jiyu Tong, Xikun Zhou, Ning Li, Qi Zhang, Hongbo Hu, WanJun Chen, Hao Xu, Dunfang Zhang   +18 more
doaj   +1 more source

Preclinical safety testing of an affinity-optimised MAGE-A10 T cell receptor for adoptive T cell therapy [PDF]

, 2015
Andrew B. Gerry, Joseph P. Sanderson, Manoj Saini, Barbara Tavano, Roslin Y. Docta, Nicholas J. Pumphrey, Miguel Maroto, E.C. Border, Alan Bennett, Gwendolyn Binder-Scholl, Tom Holdich, Lini Pandite, Rafael G. Amado, Bent K. Jakobsen   +13 more
openalex   +1 more source

Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report

, 2022
Guodai Hong, Silun Xie, Zikuan Guo, Diping Zhang, Sihai Ge, Suqin Zhang, Wenbin Gao   +6 more
openalex   +2 more sources

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy [PDF]

, 2022
Kristin G. Anderson, Shannon K. Oda, Breanna M. Bates, Madison G. Burnett, Magdalia Rodgers Suarez, Susan L. Ruskin, Philip D. Greenberg   +6 more
openalex   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Evolving insights into the improvement of adoptive T-cell immunotherapy through PD-1/PD-L1 blockade in the clinical spectrum of lung cancer

Molecular Cancer
Undeniably, cancer immunotherapies have expanded the spectrum of cancer treatment, however, some patients do not respond to immunotherapies. This scenario is no different for lung cancer, whose two main types, non-small cell lung cancer (NSCLC) and small
Yutao Li, Amit Sharma, Ingo G.H. Schmidt-Wolf   +2 more
doaj   +1 more source

Dynamic changes during the treatment of pancreatic cancer [PDF]

, 2018
This manuscript follows a single patient with pancreatic adenocarcinoma for a five year period, detailing the clinical record, pathology, the dynamic evolution of molecular and cellular alterations as well as the responses to treatments with ...
et al,, Wang-Gillam, Andrea, Wolff, Robert A   +2 more
core   +1 more source

Data from Immunomodulation of Curcumin on Adoptive Therapy with T Cell Functional Imaging in Mice

, 2023
Ya-Fang Chang, Hui‐Yen Chuang, Chien-Hui Hsu, Ren-Shyan Liu, Sanjiv S. Gambhir, Jeng‐Jong Hwang   +5 more
openalex   +1 more source