Results 161 to 170 of about 94,528 (347)

Optimumin vitroexpansion of human antigen-specific CD8+ T cells for adoptive transfer therapy [PDF]

, 2005
Monica Montes, Nathalie Rufer, Victor Appay, Stéphanie Reynard, M. J. Pittet, Daniel E. Speiser, Philippe Guillaume, J C Cerottini, Pedro Romero, Serge Leyvraz   +9 more
openalex   +1 more source

The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy [PDF]

, 2023
Ruonan Li, Lili Cao
openalex   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Minimally Clinically Important Difference of the Clinical Assessment Scale in Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The Clinical Assessment Scale in Autoimmune Encephalitis (CASE) tracks disease severity in autoimmune encephalitis (AE), but no threshold for significant change exists. We aimed to determine the minimally clinically important difference (MCID) for CASE.
Yihui Goh, Yoon Hee Shin, Soo Hyun Ahn, Su Yee Mon, Soo Jean Shin, Woo‐Jin Lee, Yoonhyuk Jang, Myoung‐Jin Jang, Soon‐Tae Lee   +8 more
wiley   +1 more source

NEO-STIM advances personalized neoantigen-specific adoptive T cell therapy

Nature Communications
Neoantigen-based adoptive T cell therapies (ACTs) represent a promising avenue in cancer immunotherapy due to their exquisite tumor specificity. The first cell-based immunotherapy for a solid tumor, comprising tumor-infiltrating lymphocytes, recently ...
Divya Lenkala, Jessica Kohler, Brian McCarthy, Michael Nelson, Noor A. M. Bakker, Renate de Boer, Emily K. Jackson, Joong Hyuk F. Sheen, Susan Hannes, Ekaterina Esaulova, Kai Stewart, Claudia Gottstein, John Attanasio, Flavian D. Brown, Sebastian Hymson, Shirisha Meda, Maaike van Zon, Saskia Scheij, Rhianne Voogd, Brenda Raud, Ziyan Xu, Jessica S. W. Borgers, Maartje W. Rohaan, Kristen N. Balogh, Asaf Poran, Michael Rooney, Jesse Z. Dong, John R. Srouji, Vikram R. Juneja, Christina M. Arieta, Cynthia M. Nijenhuis, Bastiaan Nuijen, Mark DeMario, Kelledy Manson, Ton N. M. Schumacher, Richard B. Gaynor, John B. Haanen, Joost H. van den Berg, Marit M. van Buuren   +38 more
doaj   +1 more source

P12.01 Utilizing radiation to improve adoptive cell therapy with tumor infiltrating lymphocytes [PDF]

Nina Obertopp, Anne Thomas, J. Ali, Jamie Blauvelt, Amy Hall, Heiko Enderling, Shari Pilon‐Thomas   +6 more
openalex   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Growth and Activation of Natural Killer Cells Ex Vivo from Children with Neuroblastoma for Adoptive Cell Therapy [PDF]

, 2013
Yin Liu, Hong-Wei Wu, Michael A. Sheard, Richard Sposto, Srinivas S. Somanchi, Laurence J.N. Cooper, Dean A. Lee, Robert C. Seeger   +7 more
openalex   +1 more source