Results 191 to 200 of about 94,528 (347)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Agent-based modeling of cellular dynamics in adoptive cell therapy. [PDF]

Commun Biol
Wang Y, Casarin S, Daher M, Mohanty V, Dede M, Shanley M, Dondossola E, La Posta L, Başar R, Rezvani K, Chen K.   +10 more
europepmc   +1 more source

High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D

, 2020
Malcolm J. W. Sim, Jinghua Lu, Matthew Spencer, Francis R. Hopkins, Eric Tran, Steven A. Rosenberg, Eric O. Long, Peter D. Sun   +7 more
openalex   +2 more sources

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Editorial: Implementing Logic Gates in Adoptive Cell Therapy

Frontiers in Immunology, 2022
Gideon Gross, Gideon Gross, Yaron Carmi, Hinrich Abken   +3 more
doaj   +1 more source

Tumor-infiltrating lymphocyte expansion protocols for adoptive cell therapy in cancer. [PDF]

Cell Oncol (Dordr)
Tovar Manzano D, Subhi-Issa N, Pereiro-Rodríguez A, López Cade IG, Mateos González M, Fernández Arquero M, Pérez Segura P, Ujaldón Miró C, Sánchez-Ramón S, Ocaña A, Guzmán Fulgencio M.   +10 more
europepmc   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Recent advances in adoptive cell therapy for cancer immunotherapy. [PDF]

Front Immunol
Qian J, Liu Y.
europepmc   +1 more source

Figure S1 from Targeting Cancer-Associated Glycosylation for Adoptive T-cell Therapy of Solid Tumors [PDF]

Andreas Zingg, Reto Ritschard, Helen Thut, Mélanie Buchi, Andreas Holbro, Anton Oseledchyk, Viola Heinzelmann‐Schwarz, Andreas Buser, Mascha Binder, Alfred Zippelius, Natália Rodrigues Mantuano, Matthias S. Matter, Heinz Läubli   +12 more
openalex   +1 more source

IMMU-22. ADOPTIVE CELL THERAPY AGAINST DIPG USING DEVELOPMENTALLY REGULATED ANTIGENS [PDF]

, 2017
Catherine Flores, Jorge Gil, Rebecca Abraham, Christina Pham, Tyler J. Wildes, Ginger Moore, Jeffrey Drake, Kyle Dyson, Duane A. Mitchell   +8 more
openalex   +1 more source