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Adoptive T-cell Transfer in Melanoma
Immunotherapy, 2012Immunotherapy holds a highly promising treatment approach for metastatic melanoma patients. Adoptive cell transfer (ACT) involves the ex vivo expansion of autologous antitumor reactive lymphocytes and their reinfusion into lymphodepleted patients, accompanied by IL-2 administration.
Orit, Itzhaki +6 more
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Knowledge/technology transfer and adoption
Proceedings of the 33rd Annual Hawaii International Conference on System Sciences, 2005Knowledge management is comprised of knowledge generation, transfer, accumulation, adoption, and diffusion. Contemporary technology transfer (TT) focuses on the adoption of knowledge. Technology is essentially knowledge. Transfer is the movement of knowledge/technology via some type of channel (analog or digital): person-to-person, group-to-group, and ...
D.V. Gibson +2 more
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Adoptive Transfer of Immunologic Tolerance into Normal Mice
The Journal of Immunology, 1969Abstract Preimmunization tolerance induced by injecting mice with moderate quantities of purified protein antigens in saline and preventing later attempted induction of delayed hypersensitivity by injection of these antigens in Freund's adjuvant could be broken by adoptive transfer of spleen cells from sensitized donors but not by cells ...
Crowle, A J, Hu, C C
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Adoptive Transfer of Splenocytes to Immunocompromised Mice
2012Analysis of the immune response of mice to Helicobacter infection has been greatly aided by the use of various deficient mouse strains. Here we present protocols for reconstitution of immune-deficient mice with wild-type immune cells and protocols for analysis of the outcome.
Brian M, Gray, Kathryn A, Eaton
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Isolation of Immune Cells for Adoptive Transfer
2017Adoptive transfer of T lymphocytes is a useful technique to characterize the role of the immune system in hypertension and vascular disease. Here we describe as an example the isolation of splenic T regulatory cells from donor mice processed to obtain a single cell suspension, followed by negative and positive selection to obtain CD4+ T cells and CD4 ...
Tlili, Barhoumi +3 more
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Adoptive Tolerance; Transfer of the Tolerant State
The Journal of Immunology, 1963Summary Lymphoid cells from tolerant mice can be successfully transferred to a new environment without affecting their tolerant behavior. In such transfer, both the original host and donor cells are transferred, with the establishment of a chimeric state in the irradiated recipients.
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1984
Publisher Summary This chapter describes adoptive transfer as the transfer of immunity from one animal to another by live, immunocompetent cells as opposed to immune serum or preformed antibody. It explores that the principle of adoptive transfer showed delayed-type hypersensitivity to picryl chloride could be transferred from sensitized to normal ...
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Publisher Summary This chapter describes adoptive transfer as the transfer of immunity from one animal to another by live, immunocompetent cells as opposed to immune serum or preformed antibody. It explores that the principle of adoptive transfer showed delayed-type hypersensitivity to picryl chloride could be transferred from sensitized to normal ...
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Information transfer and the adoption of agricultural innovations
Journal of the American Society for Information Science, 1990This article analyzes the way in which information transferred through different channels, i.e., mass media and interpersonal communication, influences farmers' decisions to adopt agricultural innovations. The sources through which farmers are first exposed to the new methods and/or practices are also analyzed here.
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2012
The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Donald R. Shaffer +2 more
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The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Donald R. Shaffer +2 more
openaire +1 more source
[Adoptive transfer of T lymphocytes].
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2018Within a few years, the success of treatments based on the use of T-cells armed with a chimeric T-receptor for the CD19 molecule (CAR-T CD19) has revolutionized the perception of adoptive transfer approaches. The levels of responses observed in acute leukemias, of the order of 70-90 % are indeed unprecedented.
H, Vié, B, Clémenceau
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