Results 71 to 80 of about 2,157,684 (307)

Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain

, 2011
Recent evidence demonstrates that peripheral immune cells contribute to the nociceptive hypersensitivity associated with neuropathic pain by infiltrating the central nervous system (CNS).
Hutchinson, M., Peter M. Grace, Alan Bishop, Bishop, A., Somogyi, A., Graham Mayrhofer, Andrew A. Somogyi, Rolan, P., Grace, P., Mark R. Hutchinson, Paul E. Rolan, Mayrhofer, G.   +11 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Regulatory T cells in the era of cell and gene therapy: biology, clinical translation, and future prospects

Frontiers in Immunology
Regulatory T cells (Tregs) play a central role in maintaining immune homeostasis. Therefore, owing to their unique immunomodulatory function, their adoptive transfer has been investigated as a novel therapeutic modality.
Yohei Sato, Yohei Sato, Yohei Sato
doaj   +1 more source

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer

, 2008
By transfer of T cell receptor (TCR) genes, antigen specificity of T cells can be redirected to target any antigen. Adoptive transfer of TCR-redirected T cells into patients has shown promising results.
T. Blankenstein, W. Uckert, D. Sommermeyer, Charo, J., Sommermeyer, D., Uckert, W., Kieback, E., Blankenstein, T., J. Charo, E. Kieback   +9 more
core   +1 more source

The generation of antigen-specific CD8+ T cells from stem cells for adoptive transfer immunotherapy [PDF]

, 2018
Adoptive T cell transfer is a form of immunotherapy that has shown promise in treating several cancers and post-transplant lymphoproliferative diseases.
Ooi, Tracy Peksim
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Cell Tracking in Cancer Immunotherapy

Frontiers in Medicine, 2020
The impressive development of cancer immunotherapy in the last few years originates from a more precise understanding of control mechanisms in the immune system leading to the discovery of new targets and new therapeutic tools.
Justine Perrin, Marisa Capitao, Marie Mougin-Degraef, Marie Mougin-Degraef, François Guérard, Alain Faivre-Chauvet, Alain Faivre-Chauvet, Latifa Rbah-Vidal, Joëlle Gaschet, Yannick Guilloux, Françoise Kraeber-Bodéré, Françoise Kraeber-Bodéré, Françoise Kraeber-Bodéré, Michel Chérel, Michel Chérel, Jacques Barbet   +15 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Comparative assessment of autologous and allogeneic iNKT cell transfer in iNKT cell-based immunotherapy

Frontiers in Immunology
Invariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source