Results 161 to 170 of about 188,515 (292)

Inhibition of Cell Migration by PITENINs: The Role of ARF6 [PDF]

, 2012
We have previously reported the development of small molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activation of Akt, and show anti-tumor potential.
Degterev, Alexei, Famulok, Michael, Fu, Xueyan, Miao, Benchun, Schaffhausen, Brian, Skidan, Igor, Torchilin, Vladimir, Yang, Jinsheng, You, Zerong, Yuan, Junying   +9 more
core   +1 more source

Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage

Nature Cell Biology, 2022
Huanyi Fu, Rongdiao Liu, Zixuan Jia, Ran Li, Feifeng Zhu, Wenxuan Zhu, Yangqing Shao, Yiyang Jin, Yuhua Xue, Jun Huang, K. Luo, Xiang Gao, Huasong Lu, Qiang Zhou   +13 more
semanticscholar   +1 more source

Untargeted Proteomics Identifies Plant Substrates of the Bacterial‐Derived ADP‐Ribosyltransferase AvrRpm1

Plant Direct
One class of enzymes that plant pathogens employ to manipulate innate immunity and physiology of the infected cells is host‐targeted ADP‐ribosyltransferases. The bacterial pathogen Pseudomonas syringae uses its Type III secretion system to inject several
Simranjit Kaur, Thomas Colby, Domenika Thieme, Carsten Proksch, Susanne Matschi, Ivan Matić, Lennart Wirthmueller   +6 more
doaj   +1 more source

Serine ADP-ribosylation reversal by the hydrolase ARH3

eLife, 2017
ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis. A number of proteins catalyse the transfer and hydrolysis of ADPr,
P. Fontana, J. Bonfiglio, L. Palazzo, Edward J. Bartlett, I. Matic, I. Ahel   +5 more
semanticscholar   +1 more source

The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor. [PDF]

, 1996
Andrea S. Dittié, Nasser Hajibagheri, Sharon A. Tooze   +2 more
openalex   +1 more source

Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain

Nature Communications
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category.
Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li, Jim Voorneveld, Dmitri V. Filippov, Ivan Ahel, Zhao-Qing Luo, Chittaranjan Das   +8 more
doaj   +1 more source

The PARP1/ARTD1-Mediated Poly-ADP-Ribosylation and DNA Damage Repair in B Cell Diversification

Antibodies, 2014
ADP-ribosylation is an essential post-translational modification, mediated by a family of proteins named poly-ADP-ribose polymerases/Diphtheria toxin-like ADP-ribosyltransferases (PARPs/ARTDs), that functions to assist in cellular homeostasis through an ...
Jackline J.M. Lasola, Andrea Hodgson, Xin Sun, Fengyi Wan   +3 more
doaj   +1 more source

The role of poly ADP-ribosylation in the first wave of DNA damage response

Nucleic Acids Research, 2017
Poly ADP-ribose polymerases (PARPs) catalyze massive protein poly ADP-ribosylation (PARylation) within seconds after the induction of DNA single- or double-strand breaks.
Chao Liu, Aditi Vyas, M. Kassab, Anup K Singh, Xiaochun Yu   +4 more
semanticscholar   +1 more source

ADP‐ribosylation of DNA moving into focus [PDF]

, 2017
Christian Dölle, Mathias Ziegler
openalex   +1 more source

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.

PLoS Pathogens, 2019
ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known as PARPs.
Matthew E Grunewald, Yating Chen, Chad Kuny, Takashi Maejima, Robert Lease, Dana Ferraris, Masanori Aikawa, Christopher S Sullivan, Stanley Perlman, Anthony R Fehr   +9 more
doaj   +1 more source