The centrosome–Golgi apparatus nexus [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 A shared feature among all microtubule (MT)-dependent processes is the requirement for MTs to be organized in arrays of defined geometry. At a fundamental level, this is achieved by precisely controlling the timing and localization of the nucleation ...
Rosa M Rios
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Ubiquitin-mediated degradation at the Golgi apparatus [PDF]
Frontiers in Molecular Biosciences, 2023 The Golgi apparatus is an essential organelle of the secretory pathway in eukaryotic cells. It processes secretory and transmembrane proteins and orchestrates their transport to other endomembrane compartments or the plasma membrane.
Lana Buzuk, Doris Hellerschmied
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Angewandte Chemie - International Edition, 2021 Golgi apparatus is emerging as a key signaling hub of cells and an important target for cancer therapy, but there are few approaches for targeting Golgi and selectively killing cancer cells.
Bing Xu, Hongjian He
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Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis
Frontiers in Cell and Developmental Biology, 2021 The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival, facilitating proliferation, and enabling cell-cell communication and migration.
Sarah Bui +5 more
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The endoplasmic reticulum-resident chaperone heat shock protein 47 protects the Golgi apparatus from the effects of O-glycosylation inhibition. [PDF]
PLoS ONE, 2013 The Golgi apparatus is important for the transport of secretory cargo. Glycosylation is a major post-translational event. Recognition of O-glycans on proteins is necessary for glycoprotein trafficking.
Shingo Miyata +4 more
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Intriguing role of the Golgi apparatus in astrocyte function: Implications for disorders [PDF]
Neural Regeneration ResearchCell function has a tight relationship with cell architecture. Distribution of proteins to the correct compartment is one of the functions of the traffic pathway through the Golgi apparatus.
Martina Polenghi +3 more
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The role of Dymeclin in chronic unpredictable mild stress-induced depression: maintaining the Golgi apparatus structure and regulating NLRP3 inflammasome activation [PDF]
Molecular MedicineThe Golgi apparatus plays a key role in innate immune signaling, but its exact role in depression-related neuroinflammation remains unclear. The role of Dymeclin (DYM), a Golgi structural protein, in stress-related psychiatric disorders needs further ...
Longfei Du +6 more
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The effects of WWP1 overexpression on the golgi apparatus stress response and proteoglycan production in adipocytes [PDF]
Scientific ReportsWhite adipocytes are a major component of white adipose tissue (WAT) and help to maintain systemic metabolic homeostasis by storing energy and secreting adipokines. In mice deficient in the protein WWP1 (WW domain-containing E3 ubiquitin protein ligase 1)
Yuka Nozaki +8 more
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Characterization of the glutathione redox state in the Golgi apparatus [PDF]
Redox BiologyRedox homeostasis is crucial for cell function, and, in eukaryotic cells, studying it in a compartmentalized way is essential due to the redox variations between different organelles.
Carla Miró-Vinyals +5 more
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MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migratio [PDF]
eLifeThe reorientation of the Golgi apparatus is crucial for cell migration and is regulated by multipolarity signals. A number of non-centrosomal microtubules anchor at the surface of the Golgi apparatus and play a vital role in the Golgi reorientation, but ...
Peipei Xu +10 more
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