Bridging the gap between glycosylation and vesicle traffic [PDF]
Frontiers in Cell and Developmental Biology, 2016 Glycosylation is recognised as a vitally important posttranslational modification. The structure of glycans that decorate proteins and lipids is largely dictated by biosynthetic reactions occurring in the Golgi apparatus.
Daniel eUngar, Peter eFisher
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Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis
Frontiers in Cell and Developmental Biology, 2021 The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival, facilitating proliferation, and enabling cell-cell communication and migration.
Sarah Bui +5 more
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Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion [PDF]
Journal of Virology, 2014 The replication of picornaviruses has been described to cause fragmentation of the Golgi apparatus that blocks the secretory pathway. The inhibition of major histocompatibility complex class I upregulation and cytokine, chemokine and interferon secretion
Guedan, A +7 more
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The endoplasmic reticulum-resident chaperone heat shock protein 47 protects the Golgi apparatus from the effects of O-glycosylation inhibition. [PDF]
PLoS ONE, 2013 The Golgi apparatus is important for the transport of secretory cargo. Glycosylation is a major post-translational event. Recognition of O-glycans on proteins is necessary for glycoprotein trafficking.
Shingo Miyata +4 more
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The centrosome–Golgi apparatus nexus [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 A shared feature among all microtubule (MT)-dependent processes is the requirement for MTs to be organized in arrays of defined geometry. At a fundamental level, this is achieved by precisely controlling the timing and localization of the nucleation ...
R. Rios
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Ubiquitin-mediated degradation at the Golgi apparatus [PDF]
Frontiers in Molecular Biosciences, 2023 The Golgi apparatus is an essential organelle of the secretory pathway in eukaryotic cells. It processes secretory and transmembrane proteins and orchestrates their transport to other endomembrane compartments or the plasma membrane.
Lana Buzuk, Doris Hellerschmied
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Characterization of the glutathione redox state in the Golgi apparatus [PDF]
Redox BiologyRedox homeostasis is crucial for cell function, and, in eukaryotic cells, studying it in a compartmentalized way is essential due to the redox variations between different organelles.
Carla Miró-Vinyals +5 more
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The effects of WWP1 overexpression on the golgi apparatus stress response and proteoglycan production in adipocytes [PDF]
Scientific ReportsWhite adipocytes are a major component of white adipose tissue (WAT) and help to maintain systemic metabolic homeostasis by storing energy and secreting adipokines. In mice deficient in the protein WWP1 (WW domain-containing E3 ubiquitin protein ligase 1)
Yuka Nozaki +8 more
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MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migratio [PDF]
eLifeThe reorientation of the Golgi apparatus is crucial for cell migration and is regulated by multipolarity signals. A number of non-centrosomal microtubules anchor at the surface of the Golgi apparatus and play a vital role in the Golgi reorientation, but ...
Peipei Xu +10 more
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