Results 141 to 150 of about 213,935 (349)
The role of ADP-ribosylation factor and SAR1 in vesicular trafficking in plants
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2004 Ras-like small GTP binding proteins regulate a wide variety of intracellular signalling and vesicular trafficking pathways in eukaryotic cells including plant cells. They share a common structure that operates as a molecular switch by cycling between active GTP-bound and inactive GDP-bound conformational states.
openaire +3 more sources
Mitonuclear Communication in Stem Cell Function
Cell Proliferation, EarlyView.In this review, we highlight the critical functions of mitonuclear communication and its impact on mitochondrial proteostasis. Additionally, we examine how mitonuclear signalling influences stem cell function, offering new insights into cellular homeostasis, stem cell therapies, and the potential for lifespan extension.
Baozhou Peng, Yaning Wang, Hongbo Zhang
wiley +1 more source
Neurobiology of Disease, 2021 Group I metabotropic glutamate receptors (mGluRs), mGluR1 and mGluR5, in the spinal cord are implicated in nociceptive transmission and plasticity through G protein-mediated second messenger cascades leading to the activation of various protein kinases ...
Akiko Ito +6 more
doaj
A Schmid-Leiman based transformation resulting in perfect inter-correlations of three types of factor score predictors [PDF]
arXiv, 2015 Factor score predictors are to be computed when the individual scores on the factors are of interest. Conditions for a perfect inter-correlation of the regression/best linear factor score predictor, the best linear conditionally unbiased predictor, and the determinant best linear correlation-preserving predictor are presented. When these three types of
arxiv
ADP-Ribosylation factors do not activate yeast phospholipase Ds but are required for sporulation.
Molecular Biology of the Cell, 1998 ADP-ribosylation factor (ARF) proteins in Saccharomyces cerevisiae are encoded by two genes, ARF1 and ARF2. The addition of the c-myc epitope at the C terminus of Arf1 resulted in a mutant (arf1-myc arf2) that supported vegetative growth and rescued ...
S. Rudge +6 more
semanticscholar +1 more source
ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus. [PDF]
, 2013 Small GTPases of the ADP-ribosylation factor (ARF) family, except for ARF6, mainly localize to the Golgi apparatus, where they trigger formation of coated carrier vesicles.
Kondo, Yumika +5 more
core +1 more source
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition
The FEBS Journal, EarlyView.The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda +5 more
wiley +1 more source
Journal of Biological Chemistry, 1996 Clathrin coat assembly in the trans-Golgi network, leading to the sequestration of the mannose 6-phosphate receptors (MPRs) into nascent vesicles, requires the ARF-1-dependent translocation of the cytosolic AP-1 Golgi assembly proteins onto the membranes
R. L. Borgne, G. Griffiths, B. Hoflack
semanticscholar +1 more source
Regulation of skeletal muscle development and homeostasis by gene imprinting, histone acetylation and microRNA [PDF]
, 2015 Epigenetics is defined as heritable information other that the DNA sequence itself. The concept implies that the regulation of gene expression is highly complex and epigenetics can control from fine tuning to permanent gene activation/deactivation ...
ADAMO, Sergio +3 more
core +2 more sources
WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution
The FEBS Journal, EarlyView.WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert +16 more
wiley +1 more source