Results 181 to 190 of about 213,935 (349)

G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials

open access: yesMedicinal Research Reviews, Volume 45, Issue 3, Page 985-1015, May 2025.
ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis   +10 more
wiley   +1 more source

How to improve the regression factor score predictor when individuals have different factor loadings [PDF]

open access: yesarXiv
Previous research has shown that ignoring individual differences of factor loadings in conventional factor models may reduce the determinacy of factor score predictors. Therefore, the aim of the present study is to propose a heterogeneous regression factor score with larger determinacy than the conventional regression factor score when individuals have
arxiv  

Primitive factorizations, Jucys-Murphy elements, and matrix models [PDF]

open access: yesarXiv, 2010
A factorization of a permutation into transpositions is called "primitive" if its factors are weakly ordered. We discuss the problem of enumerating primitive factorizations of permutations, and its place in the hierarchy of previously studied factorization problems.
arxiv  

Identification of Novel Candidate Genes Associated With the Symbiotic Compatibility of Soybean With Rhizobia Under Natural Conditions

open access: yesPlant Direct, Volume 9, Issue 5, May 2025.
ABSTRACT A robust symbiotic relationship between soybean and rhizobia can enhance the yield and quality of soybeans by reducing nitrogen fertilizer input, thereby contributing to sustainable agriculture. However, the genetic interplay between soybean cultivars and the rhizobial species colonizing their roots under natural conditions is yet to be ...
Masayoshi Teraishi   +2 more
wiley   +1 more source

Factorization of Motion Polynomials [PDF]

open access: yesarXiv, 2015
In this paper, we consider the existence of a factorization of a monic, bounded motion polynomial. We prove existence of factorizations, possibly after multiplication with a real polynomial and provide algorithms for computing polynomial factor and factorizations.
arxiv  

Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
USP13 is a promising therapeutic target for cellular proliferation in multiple myeloma. Bruceine A can retard the development of multiple myeloma by targeting USP13/PARP1‐mediated DNA damage repair and triggering cell apoptosis. ABSTRACT Multiple myeloma (MM) is an incurable hematologic malignancy, driving significant interest in the discovery of novel
Mengjie Guo   +9 more
wiley   +1 more source

Determination of Immunological Properties of Pseudomonas aeroginosa PA103, by Serum Bactericidal Assay & ELISA

open access: yesJournal of Medical Bacteriology
Background:   Exotoxin A (ExoA) is one of the most known and important virulence factors of Pseudomonas aeruginosa. This toxin is the cause of ADP-ribosylation in eukaryutic Elongation Factor-2 (EF-2), which results in the protein synthesis ...
Shahrzad Aliniay Sharafshadehi   +8 more
doaj   +1 more source

Short Exposure to Full Moonlight Has a Long‐Term Impact on Brassica juncea Cell Activity and Growth

open access: yesPlant, Cell &Environment, Volume 48, Issue 5, Page 3038-3051, May 2025.
ABSTRACT Lunar farming, often regarded as a myth, is regularly practiced in many places around the world (e.g., India) where framers organized their agricultural activities according to moon phases. Early and recent work showed that exposure to moonlight affects the life cycle of plants, from seed germination and vegetative growth to fruit maturation ...
Govindegowda Priyanka   +3 more
wiley   +1 more source

Transcriptomic Response of Balamuthia mandrillaris to Lippia graveolens Extract Fractions

open access: yesMicrobiology Research
Balamuthia mandrillaris is a free-living amoeba pathogenic to humans, causing amoebic granulomatous encephalitis (GAE). Due to the associated mortality rates of
Leobardo Daniel Gonzalez-Zuñiga   +8 more
doaj   +1 more source

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