Results 51 to 60 of about 45,797 (235)

ADP-ribosylation factor machinery mediates endocytosis in plant cells [PDF]

Proceedings of the National Academy of Sciences, 2010
Endocytosis is crucial for various cellular functions and development of multicellular organisms. In mammals and yeast, ADP-ribosylation factor (ARF) GTPases, key components of vesicle formation, and their regulators ARF-guanine nucleotide exchange factors (GEFs) and ARF-GTPase-activating protein (GAPs) mediate endocytosis.
Satoshi, Naramoto, Jürgen, Kleine-Vehn, Stéphanie, Robert, Masaru, Fujimoto, Tomoko, Dainobu, Tomasz, Paciorek, Takashi, Ueda, Akihiko, Nakano, Marc C E, Van Montagu, Hiroo, Fukuda, Jirí, Friml   +10 more
openaire   +2 more sources

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Control of T lymphocyte morphology by the GTPase Rho [PDF]

, 2003
Background Rho family GTPase regulation of the actin cytoskeleton governs a variety of cell responses. In this report, we have analyzed the role of the GTPase Rho in maintenance of the T lymphocyte actin cytoskeleton.
Andruss, Bernard F, Caudell, Eva G, McIntyre, Bradley W, Miyamoto, Yuko J, Teague, T Kent, Udagawa, Taturo, Woodside, Darren G, Wooten, David K   +7 more
core   +2 more sources

Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1

Nature Communications
The chromatin remodeler ALC1 is activated by DNA damage-induced poly(ADP-ribose) deposited by PARP1/PARP2 and their co-factor HPF1. ALC1 has emerged as a cancer drug target, but how it is recruited to ADP-ribosylated nucleosomes to affect their ...
Luka Bacic, Guillaume Gaullier, Jugal Mohapatra, Guanzhong Mao, Klaus Brackmann, Mikhail Panfilov, Glen Liszczak, Anton Sabantsev, Sebastian Deindl   +8 more
doaj   +1 more source

Arf GTPase-activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor

Biology Open, 2021
Arf GTPase-Activating proteins (ArfGAPs) mediate the hydrolysis of GTP bound to ADP-ribosylation factors (Arfs), which are critical to form transport intermediates.
Asano Watanabe, Hikari Hataida, Naoya Inoue, Kosuke Kamon, Keigo Baba, Kuniaki Sasaki, Rika Kimura, Honoka Sasaki, Yuka Eura, Wei-Fen Ni, Yuji Shibasaki, Satoshi Waguri, Koichi Kokame, Yoko Shiba   +13 more
doaj   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Are guanine nucleotide binding proteins a distinct class of regulatory proteins? [PDF]

, 1983
Proteins which bind guanine nucleotides are found in a diverse set of key regulatory positions. They are involved in hormone action, visual transduction, protein synthesis and microtubule assembly. In addition to their ability to bind guanine nucleotides
Kleinzeller, Cassel, Martin, Pfeuffer, Hanski, Northup, Northup, Rodbell, Cooper, Houslay, Manning, Johnson, Bokoch, Zahniser, Stryer, Kuhn, Fung, Baehr, Hurley, Hughes, Yamazaki, Abood, Bitensky, Kawamura, Kawamura, Emeis, Swarup, Maitra, Schreier, Safer, Safer, Fakunding, Brot, Hachmann, Uchida, Collier, Montanaro, Beaudet, Laursen, Velenzuela, Spiegelman, Carlier, Zackroff, Weisenberg, Heyworth, Heyworth, Goodhardt, Shih, Capon, Willingham   +49 more
core   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Opposite Regulatory Effects of Iron Ions on the In Vitro Catalytic Activities of NarE, the Toxin-like ADP-ribosyltransferase from Neisseria meningitidis [PDF]

, 2015
NarE, the mono ADP-ribosyltransferase identified in Neisseria meningitidis, catalyzes three enzymatic reactions. NarE transfers a single ADP-ribose unit to guanidine compounds, hydrolyses NAD in nicotinamide and free ADP-ribose, and ADP-ribosylates ...
Balducci, Enrico, Del Vecchio, Mariangela   +1 more
core   +1 more source