Results 71 to 80 of about 7,446,455 (132)

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, Volume 101, Issue 5, Page 2103-2118, October 2026.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis.

PLoS Biology, 2006
Fcgamma receptor (FcgammaR)-mediated phagocytosis of IgG-coated particles is regulated by 3'-phosphoinositides (3'PIs) and several classes of small GTPases, including ARF6 from the ADP Ribosylation Factor subfamily.
Peter Beemiller, Adam D Hoppe, Joel A Swanson   +2 more
doaj   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

Characterization of shikonin derivative secretion in Lithospermum eryrhirorizon hairy roots as a model of lipid-soluble metabolite secretion from plants.

Frontiers in Plant Science, 2016
Shikonin derivatives are specialized lipophilic metabolites, secreted in abundant amounts from the root epidermal cells of Lithospermum erythrorhizon.
Kanade Tatsumi, Mariko Yano, Kenta Kaminade, Akifumi Sugiyama, Mayuko Sato, Kiminori Toyooka, Takashi Aoyama, Fumihiko Sato, Kazufumi Yazaki   +8 more
doaj   +1 more source

A cross‐species post‐translational modification profiling of histones by LC‐MS/MS revealed conserved oxidative modifications in plants

New Phytologist, Volume 252, Issue 2, Page 538-545, October 2026.
Conservation of post‐translational modifications (PTMs) in histones across six plant species.
Sau‐Shan Cheng, Wai‐Ching Sin, Yuen‐Yi Chau, Hon‐Ming Lam   +3 more
wiley   +1 more source

Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer

Cellular and Molecular Life Sciences
Poly(ADP-ribose)polymerase 2 (PARP2) is a nuclear protein, DNA damage sensor and an emerging target for development of anti-cancer drugs. Previously it was discovered that PARP2 binds to nucleosomes; however, critical factors involved in this process ...
Natalya Maluchenko, Alexandra Saulina, Olga Geraskina, Elena Kotova, Anna Korovina, Grigoriy Armeev, Mikhail Kirpichnikov, Alexey Feofanov, Vasily Studitsky   +8 more
doaj   +1 more source

Analyzing the safety of the parasiticide fungus Mucor circinelloides: first insights on its virulence profile and interactions with the avian gut microbial community

Microbiology Spectrum
Parasiticide fungi are considered an accurate, sustainable, and safe solution for the biocontrol of animal gastrointestinal (GI) parasites. This research provides an initial characterization of the virulence of the native parasiticide fungus Mucor ...
João Lozano, Eva Cunha, Cristina Almeida, Mónica Nunes, Ricardo Dias, Eduardo Vicente, Daniela Sebastião, Sérgio Henriques, Luís Madeira de Carvalho, Adolfo Paz-Silva, Manuela Oliveira   +10 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, Volume 600, Issue 17, Page 2564-2578, September 2026.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source