Results 91 to 100 of about 7,446,455 (132)

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Studying catabolism of protein ADP-ribosylation [PDF]

, 2016
Protein ADP-ribosylation is a conserved post-translational modification that regulates many major cellular functions, such as DNA repair, transcription, translation, signal transduction, stress response, cell division, aging and cell death.
James, Dominic, Luca Palazzo, Ivan Ahel, Waddell, Ian, Ian D. Waddell, Palazzo, Luca, Ahel, Ivan, Palazzo, L, Ahel, I, Dominic I. James, James, DI, Waddell, ID   +11 more
core   +1 more source

Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng   +5 more
wiley   +1 more source

Metalorganic Titanium Treatment to Change Enamel Optical Properties

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 9, September 2026.
ABSTRACT Observational studies have shown that human teeth with higher concentrations of titanium traces have better optical properties. The aim of this study was to investigate how titanium ion infiltration into tooth enamel affects its optical properties by studying the diffusion and reactivity of titanium compounds in tooth enamel and how this ...
Yara Oweis, Amir Elhadad, Sophia Smith, Qiman Gao, Emily Buck, Mohamed‐Amine Mezour, Wenge Jiang, Javier Vargas Balbuena, Sailer S. Dos Santos, Marta Cerruti, Faleh Tamimi   +10 more
wiley   +1 more source

ADP-ribosylation of BSA by Pertussigen Follows the same Mechanism as ADP-ribosylation of Transducine [PDF]

, 1986
Pertussigen is a toxin responsible for the ADP-ribosylation of the Adenylate cyclase system inhibitory component. It has been verified through polyacrylamide gel electrophoresis that the ADP-ribosylation occurs only if the reaction mixture is ...
Cabrera, John
core   +1 more source

USP34 Haploinsufficiency as a Cause of Neurodevelopmental Phenotypes

Clinical Genetics, Volume 110, Issue 3, Page 315-324, September 2026.
Heterozygous loss‐of‐function variants in USP34 cause a novel neurodevelopmental disorder characterized by global developmental delay, speech impairment, autism, hypotonia, craniofacial dysmorphism, and distal limb anomalies. Disrupted Wnt/β‐catenin signaling via reduced Axin stabilization refines gene‐specific contributions within 2p15p16.1 ...
Helena Wigoda, Amjad Khan, Bryce A. Mendelsohn, Noriko Miyake, Nobuhiko Okamoto, Naomichi Matsumoto, Patricia J. C. Knijnenburg, Johanna M. van Hagen, Jiddeke van de Kamp, Quinten Waisfisz, Bryn D. Webb   +10 more
wiley   +1 more source

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, Volume 293, Issue 18, Page 5514-5540, September 2026.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source

Interactional Endocytosis and Transmembrane Transport Promote Cellular Internalization of Nano‐Delivered RNA Drugs for Efficient Control of Crop Diseases

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5152-5171, September 2026.
ABSTRACT Botrytis cinerea is a widespread plant pathogenic ascomycete that causes grey mould in over 1400 species and impacts global crop yields. Double‐stranded RNA (dsRNA)‐induced gene silencing is a promising technology for pest control, but efficient delivery remains a major challenge.
Mei Guan, Chao Xie, Yang Xue, Juan Lu, Qinhong Jiang, Meizhen Yin, Shuo Yan, Jie Shen   +7 more
wiley   +1 more source

Cell fate regulation by chromatin ADP-ribosylation

, 2017
ADP-ribosylation is an evolutionarily conserved complex posttranslational modification that alters protein function and/or interaction. Intracellularly, it is mainly catalyzed by diphtheria toxin-like ADP-ribosyltransferases (ARTDs), which attach one or ...
Michael O. Hottiger, Abplanalp, Jeannette, Hottiger, Michael O, Jeannette Abplanalp   +3 more
core   +1 more source

Interview With Barbara Pearse and the Clathrin Family Tree

Traffic, Volume 27, Issue 3, September 2026.
The clathrin family tree. Timeline of research on clathrin leading to and generated by Barbara Pearse's discovery, with milestones mapped onto the clathrin triskelion.
Frances M. Brodsky, Margaret S. Robinson
wiley   +1 more source