Results 111 to 120 of about 45,797 (235)

Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling

EMBO Reports
Tight control of cGAS-STING-mediated DNA sensing is crucial to avoid auto-inflammation. The GTPase ADP-ribosylation factor 1 (ARF1) is crucial to maintain cGAS-STING homeostasis and various pathogenic ARF1 variants are associated with type I ...
Johannes Lang, Tim Bergner, Julia Zinngrebe, Alice Lepelley, Katharina Vill, Steffen Leiz, Meinhard Wlaschek, Matias Wagner, Karin Scharffetter-Kochanek, Pamela Fischer-Posovszky, Clarissa Read, Yanick J Crow, Maximilian Hirschenberger, Konstantin M J Sparrer   +13 more
doaj   +1 more source

Posttranslational Modification in Bone Homeostasis and Osteoporosis

MedComm
Bone is responsible for providing mechanical protection, attachment sites for muscles, hematopoiesis micssroenvironment, and maintaining balance between calcium and phosphorate.
Yuzhe Lin, Shide Jiang, Yuming Yao, Hengzhen Li, Hongfu Jin, Guang Yang, Bingzhou Ji, Yusheng Li   +7 more
doaj   +1 more source

Transcriptomic Response of Balamuthia mandrillaris to Lippia graveolens Extract Fractions

Microbiology Research
Balamuthia mandrillaris is a free-living amoeba pathogenic to humans, causing amoebic granulomatous encephalitis (GAE). Due to the associated mortality rates of
Leobardo Daniel Gonzalez-Zuñiga, Jose Reyes Gonzalez-Galaviz, Abraham Cruz-Mendívil, Fernando Lares Villa, Erick Paul Gutiérrez-Grijalva, Jaime López-Cervantes, Dalia I. Sánchez-Machado, Luis Fernando Lares-Jiménez, Libia Zulema Rodriguez-Anaya   +8 more
doaj   +1 more source

ARF1 contrôle la migration des cellules hautement invasives du cancer du sein via Rac1 [PDF]

, 2012
Dans un contexte où la forte prévalence du cancer du sein chez les femmes demeure depuis plusieurs années un enjeu de société majeur, les nouvelles stratégies visant à réduire la mortalité associée à cette maladie sont le sujet de nombreuses recherches ...
Lewis-Saravalli, Sebastian
core  

Effect of oxidative stress, produced by cumene hydroperoxide, on the various steps of protein synthesis. Modifications of elongation factor-2 [PDF]

, 1996
We have studied the effect of oxidative stress on protein synthesis in rat liver. Cumene hydroperoxide (CH) was used as an oxidant agent. The approach used was to determine the ribosomal state of aggregation and the time for assembly and release of ...
Ayala Gómez, Antonio, Bougria, Mohammed, Machado Quintana, Alberto, Parrado Rubio, Juan   +3 more
core  

The potential of ARL4C and its-mediated genes in atherosclerosis and agent development

Frontiers in Pharmacology
Foam cells are the risk factors for atherosclerosis. Recently, ARL4C, a member of the ADP-ribosylation factor family of GTP-binding proteins, was found to promote cholesterol efflux to decrease foam cell formation, suggesting that ARL4C may be a new ...
Dan Liu, Jie Wang, Shuangshuang Zhang, Hongfei Jiang, Yudong Wu, Chao Wang, Wujun Chen, Wujun Chen   +7 more
doaj   +1 more source

Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments. [PDF]

J Neurosci, 2019
Hosoi N, Shibasaki K, Hosono M, Konno A, Shinoda Y, Kiyonari H, Inoue K, Muramatsu SI, Ishizaki Y, Hirai H, Furuichi T, Sadakata T.   +11 more
europepmc   +1 more source

"Your funeral... my trial": a review of the mechanisms leading to cancer cells death when targeting nicotinamide adenine dinucleotide [PDF]

, 2014
Le nicotinamide adénine dinucléotide (NAD) est un métabolite jouant un rôle crucial dans la vie cellulaire. Dans la mitochondrie, il est surtout utilisé comme co-enzyme d'oxydo-réduction afin de produire de l'énergie sous forme d'ATP (respiration ...
MORISOD, L.
core  

ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs

Frontiers in Molecular Biosciences
ADP-ribosylation factors (ARFs) are GTP-binding proteins that were discovered in the early 1980s, shortly after heterotrimeric GTP-binding proteins (G proteins) and nearly simultaneously with RAS.
Rachel E. Turn, Joel Bryan Dacks, Eric M. Rosenberg, Olivier Soubias, John K. Northup, Paul A. Randazzo   +5 more
doaj   +1 more source

Structure, organization and evolution of ADP-ribosylation factors in rice and foxtail millet, and their expression in rice. [PDF]

Sci Rep, 2016
Muthamilarasan M, Mangu VR, Zandkarimi H, Prasad M, Baisakh N.   +4 more
europepmc   +1 more source