Results 101 to 110 of about 7,446,455 (132)

Membrane-association promotes Axin degradation through Tankyrase-dependent ADP-ribosylation

, 2016
(A) Lysates from third instar larvae expressing indicated transgenes with the C765-Gal4 driver were analyzed by immunoblotting. Myr-Axin-V5 is present at much lower levels than Axin-V5 or MyrG-A-Axin-V5. Kinesin was used as a loading control.
Yashi Ahmed (2158360), Zhenghan Wang (2158363), Ofelia Tacchelly-Benites (3396215), Eungi Yang (251227)   +3 more
core   +1 more source

Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling

EMBO Reports
Tight control of cGAS-STING-mediated DNA sensing is crucial to avoid auto-inflammation. The GTPase ADP-ribosylation factor 1 (ARF1) is crucial to maintain cGAS-STING homeostasis and various pathogenic ARF1 variants are associated with type I ...
Johannes Lang, Tim Bergner, Julia Zinngrebe, Alice Lepelley, Katharina Vill, Steffen Leiz, Meinhard Wlaschek, Matias Wagner, Karin Scharffetter-Kochanek, Pamela Fischer-Posovszky, Clarissa Read, Yanick J Crow, Maximilian Hirschenberger, Konstantin M J Sparrer   +13 more
doaj   +1 more source

A Commander-independent function of COMMD3 in endosomal trafficking

eLife
Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradation in lysosomes.
Galen T Squiers, Chun Wan, James Gorder, Harrison Puscher, Jingshi Shen   +4 more
doaj   +1 more source

Hormonal stimulation of eucaryotic cell ADP-ribosylation.

, 1981
The effect of thyrotropin (TSH) on the ADP-ribosylation of endogenous thyroid cell acceptor proteins was examined. Cells were "permeabilized" at 4 degrees C in hypotonic medium and then exposed to [(32)P]- or [(3)H-adenine]NAD(+).
B. Rapoport, FILETTI, SEBASTIANO, Sebastiano Filetti, Basil Rapoport   +3 more
core   +1 more source

Transcriptomic Response of Balamuthia mandrillaris to Lippia graveolens Extract Fractions

Microbiology Research
Balamuthia mandrillaris is a free-living amoeba pathogenic to humans, causing amoebic granulomatous encephalitis (GAE). Due to the associated mortality rates of
Leobardo Daniel Gonzalez-Zuñiga, Jose Reyes Gonzalez-Galaviz, Abraham Cruz-Mendívil, Fernando Lares Villa, Erick Paul Gutiérrez-Grijalva, Jaime López-Cervantes, Dalia I. Sánchez-Machado, Luis Fernando Lares-Jiménez, Libia Zulema Rodriguez-Anaya   +8 more
doaj   +1 more source

The potential of ARL4C and its-mediated genes in atherosclerosis and agent development

Frontiers in Pharmacology
Foam cells are the risk factors for atherosclerosis. Recently, ARL4C, a member of the ADP-ribosylation factor family of GTP-binding proteins, was found to promote cholesterol efflux to decrease foam cell formation, suggesting that ARL4C may be a new ...
Dan Liu, Jie Wang, Shuangshuang Zhang, Hongfei Jiang, Yudong Wu, Chao Wang, Wujun Chen, Wujun Chen   +7 more
doaj   +1 more source

Posttranslational Modification in Bone Homeostasis and Osteoporosis

MedComm
Bone is responsible for providing mechanical protection, attachment sites for muscles, hematopoiesis micssroenvironment, and maintaining balance between calcium and phosphorate.
Yuzhe Lin, Shide Jiang, Yuming Yao, Hengzhen Li, Hongfu Jin, Guang Yang, Bingzhou Ji, Yusheng Li   +7 more
doaj   +1 more source

RBOHC‐Generated ROS Tune MIZ2/GNOM‐Dependent Root Halotropism in Arabidopsis

Plant, Cell &Environment, Volume 49, Issue 9, Page 7151-7154, September 2026.
Amir Cohen, Matan Franko, Yvonne Kiere, Yonatan Wexler, Doron Shkolnik   +4 more
wiley   +1 more source

ARL13B is regulated by the ERK/P90 pathway and mediates TMZ resistance in glioblastoma via microvesicles

Scientific Reports
Temozolomide (TMZ) resistance presents a serious challenge in glioma treatment. It has been revealed that high expression of ADP-ribosylation factor-like GTPase 13B (ARL13B) is an important risk factor for glioma patients and is strongly related to RHO ...
Haichao Xing, Ying Chen, Haolin Li, Mingjie Wang, Yujing Cao, Xiaomin Liu   +5 more
doaj   +1 more source

Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesions

International audiencePoly(ADP-ribose) polymerase 1 (PARP1) has emerged as a central target for cancer therapies due to the ability of PARP inhibitors to specifically kill tumors deficient for DNA repair by homologous recombination.
Chapuis, Catherine, Duma, Lena, Imburchia, Victor, Schützenhofer, Kira, Ahel, Ivan, Huet, Sébastien, Zentout, Siham, Prokhorova, Evgeniia, Smith, Rebecca   +8 more
core   +1 more source